Synthetic Antibacterials. VII. N-(1,8-Naphthyridin-7-yl)-methylenamine Derivatives

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概要

• 論文の詳細を見る

• Treatment of ethyl 1,4-dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate (1) with selenium dioxide afforded a mixture of ethyl 1,4-dihydro-1-ethyl-7-formyl-4-oxo-1,8-naphthyridine-3-carboxylate (2) and 1,4-dihydro-1-ethyl-7-formyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (3). Condensation of 2 or 3 with respective amines provided the corresponding N-(1,4-dihydro-3-ethoxycarbonyl-1-ethyl-4-oxo-1,8-naphthyridin-7-yl) methylenamine (4-15) and N-(3-carboxy-1,4-dihydro-1-ethyl-4-oxo-1,8-naphthyridin-7-yl) methylenamine (16-27), respectively. These compounds were tested for in vitro antibacterial activity.

• 社団法人日本薬学会の論文
• 1977-02-25

著者

• 千賀 慶太郎

  Pharmaceutical Institute, School of Medicine, Keio, University

• 千賀 慶太郎

  Pharmaceutical Institute School Of Medicine Keio University

• 水島 規子

  Pharmaceutical Institute School Of Medicine Keio University

• 千賀 慶太郎

  慶応大 病院

• 千賀 慶太郎

  慶応義塾大学病院薬剤部

• 西垣 貞男

  Pharmaceutical Institute, School of Medicine, Keio University

• 西垣 貞男

  Pharmaceutical Institute School Of Medicine Keio University

• 西垣 貞男

  慶応義塾大学病院

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