Asymmetric Reduction with 5-Deazaflavin. II. : Synthesis of Some Chiral 5-Deazaflavin Derivatives

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概要

• 論文の詳細を見る

• For the purpose of development of functional biomimetic coenzyme models, we prepared some new types of chiral 5-deazaflavin derivatives. Syntheses of 5-deazaflavin derivatives possessing a chiral substituent at the C(6) position, (13), and a chiral tertiary asymmetric carbon center at C(5) (15a, b, 17a, b, and 18a, b) were achieved in rather satisfactory yield. Preliminary experiments on asymmetric reduction of ethyl benzoylformate with 15a, b were carried out in order to investigate the efficiency of the models thus obtained, resulting in moderate or low asymmetric induction.

• 公益社団法人日本薬学会の論文
• 1990-02-25

著者

• 米田 文郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 田中 圭

  Faculty Of Pharmaceutical Sciences Kyoto University

• 田中 圭

  静岡県大 薬

• 陳 星

  Faculty Of Pharmaceutical Sciences Kyoto University

• 木村 禎治

  Faculty of Pharmaceutical Sciences, Kyoto University

• 米田 文郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 川本 哲治

  Faculty of Pharmaceutical Sciences, Kyoto University

• 木村 禎治

  Faculty Of Pharmaceutical Sciences Kyoto University

• 田中 圭

  京都大学薬学部

• 川本 哲治

  Faculty Of Pharmaceutical Sciences Kyoto University

• 田中 圭

  Faculty of Eng., Oita Univ.

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