Synthesis and Properties of 2,3,4,8-Tetrahydro-2,4-dioxopyrido [2,3-d]-pyrimidines (5-Deazalumazines) and Their Bis-compounds
スポンサーリンク
概要
- 論文の詳細を見る
Ethyl 2,3,4,8-tetrahydro-3-methyl-2,4-dioxopyrido [2,3-d] pyrimidine-6-carboxylates (IV) and their bis-compounds (VI) were synthesized by the condensation of 6-alkyl-or 6-aryl-amino-3-methyluracils (II) and appropriate ethyl 3-chloro-2-formylprop-2-enoates (III) in dimethylformamide. Hydrolysis of the esters IV and VI with base resulted in a novel rearrangement of a substituent (R^2) at the 7-position onto the 6-substituent to give the corresponding 6-acyl-1,2,3,4,7,8-hexahydro-3-methyl-2,4,7-trioxopyrido [2,3-d] pyrimidines (VII) and their bis-compounds (X). The mechanism of the rearrangement is discussed.
- 公益社団法人日本薬学会の論文
- 1984-05-25
著者
-
米田 文郎
Faculty Of Pharmaceutical Sciences Kyoto University
-
永松 朝文
Faculty Of Pharmaceutical Sciences Okayama University
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古賀 理和
Faculty Of Pharmaceutical Sciences Kyoto University
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