ラタモキセフ2ナトリウムの水溶液及び5%ブドウ糖配合注射液中での安定性

概要

論文の詳細を見る
The stability of disodium latamoxef in aqueous solution and compatibility in 5% glucose solution at 25°C were studied. Disodium latamoxef for injection was found to be composed of R(-)-epimer and S(+)-epimer in the ratio of 1 : 0.91. The hydrolysis rates of both epimers were identical and the pH-rate profile was obtained. The rate law describing water-catalyzed hydrolysis of each molecular species and hydroxide ion-catalyzed hydrolysis of di- and tri-anions gave the best fits to the experimental results. The apparent activation energies at pH 3.0,6.0 and 9.0 were 16.5,19.2 and 27.1 kcal mol^<-1>, respectively. The 10% loss time (t_<0.9>) at pH 4-7 and 25°C was predicted to be 30-33 h. The remaining ratios at 6 and 24 h were predicted to be 98.1 and 92.6%, respectively. The stability in the admixture was almost similar to the predicted values, suggesting that pH is a primary factor. For the additives studied, it was concluded that the admixture of 5-fluorouracil injection should be administered within 6 h and tegafur injection (Futraful〓) is incompatible.
公益社団法人日本薬学会の論文
1986-01-25