クロルヘキシジンと低濃度エタノールとの併用による消毒効果

概要

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The bactericidal actions of chlorhexidine alone and in combination with low concentration of ethanol were examined for several organisms already reported to be resistant to chlorhexidine. Of the species tested, Pseudomonas aeruginosa, Acinetobacter calcoaceticus, Providencia stuartii and Proteus mirabilis were completely killed by exposure, for 10 min at 20℃, of 0.02 or 0.5% chlorhexidine, but Flavobacterium meningosepticum and Achromobacter xylosoxidans were resistant to 0.02% chlorhexidine and P. cepacia showed the resistance to both 0.02% and 0.5% chlorhexidine. The concentration of 0.02 or 0.5% chlorhexidine in the presence of 10% ethanol, however, was sufficient to induce a complete loss of viability in the above-mentioned resistant species. The combination of chlorhexidine and diluted ethanol might be useful for the disinfection in hospital practice as this acts synergistically with strong bactericidal activity.
社団法人日本薬学会の論文
1984-07-25