桜皮エキス配合内用液剤の微生物汚染とその対策

概要

論文の詳細を見る
Cherry bark extract oral liquid preparations are widely used. These preparation are obtained by adding senega syrup, apricot kernel water, and water to cherry bark extract (Brocin^<[○!R]>). We investigated microbial contamination in the residual fluid after patients had taken cherry bark extract oral liquid preparations. Of 29 examined samples, 15(52%) showed microbial contamination with a viabie count ≧20 CFU/ml. The viable count level was 10^4-10^5CFU/ml in three samples (10%), 10^3CFU/ml in one ( 4 %), and 10-10^2 CFU/ml in 11(38%). To prevent microbial contamination in these preparations, it is necessary to avoid the use of the method in which water is added to obtain a daily liquid preparation volume of 100 ml. Specifically, the addition of water should be avoided, or the water volume should be decreased to obtain a dally liquid preparation volume of 20-40 ml.
日本医療薬学会の論文
1996-06-10