DT-5621(ブクラデシン軟膏)の配合変化試験

概要

論文の詳細を見る
The compatibility of DT-5621 (Bucladesine ointment), a new anti-skin ulcer agent, with seven kinds of topical agents was studied. DT-5621 was mixed with each topical agent in equal weight, and the mixtures were allowed to stand during 14 days at 10℃. The kneading uniformity, the property change and the color change were recorded for each mixture 0 hour, 24 hours and 14 days after mixing. The content or potency of each component in the mixtures were also measured. The contents of DT-5621. Geben^[○!R] cream, and Anderm^[○!R] ointment were determined by the HPLC method, and the potency of Gentacin^[○!R], Panimycin^[○!R], and Achromycin^[○!R] ointments were estimated by the bioassay method. The potency of Isodine^[○!R] gel was assayed by iodometry method and the content of Betonevate^[○!R] by spectrophotometry. No change was observed in all experiments except for the color change of DT-5621 and Achromycin^[○!R] ointment mixture after 14 days, indicating that DT-5621 is compatible with the six commercial topical agents (Gentacin^[○!R], panimycin^[○!R], Isodine^[○!R], Geben^[○!R], Anderm^[○!R], Betonevate^[○!R]). DT-5621 is compatible with Achromycin^[○!R] ointment if the mixture is prepared immediately before using.
日本医療薬学会の論文
1991-06-20