Synthese and Antifungal Activity of dl-Griseofulvin and Its Congeners. III

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概要

• 論文の詳細を見る

• Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d>1b, c≫1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

• 公益社団法人日本薬学会の論文
• 1997-12-15

著者

• 竹内 洋文

  50周年誌編集小委員会

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• 原山 尚

  Faculty Of Pharmaceutical Sciences Kyoto University

• Yamato M

  Okayama Univ. Science Okayama Jpn

• Yamato M

  Faculty Of Science Okayama University Of Science

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• TAKEUCHI Yasuo

  Faculty of Pharmaceutical Sciences, Okayama University

• HARAYAMA Takashi

  Faculty of Pharmaceutical Sciences, Okayama University

• Hirose Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Hirose Yoko

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Watanabe I

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Toho University

• Harayama Takashi

  Faculty Of Pharmaceutical Sciences Okayama University

• YAMATO Masatoshi

  Faculty of Pharmaceutical Sciences, Okayama University

• WATANABE Ikuo

  Faculty of Pharmaceutical Sciences, Okayama University

• MISUMI Keiji

  Faculty of Pharmaceutical Sciences, Okayama University

• IRIE Mari

  Faculty of Pharmaceutical Sciences, Okayama University

• HIRATA Kazumi

  Faculty of Pharmaceutical Sciences, Okayama University

• Misumi Keiji

  Faculty Of Pharmaceutical Sciences Okayama University

• Irie Mari

  Faculty Of Pharmaceutical Sciences Okayama University

• Hirata Kazumi

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamato Masatoshi

  Faculty Of Pharmaceutical Sciences Okayama University

• Takeuchi Yasuo

  Faculty Of Pharmaceutical Sciences Okayama University

• Harayama Takashi

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

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