Enhancement of Propylene Glycol Distribution in the Skin by High Purity cis-Unsaturated Fatty Acids with Different Alkyl Chain Lengths Haiving Different Double Bond Position

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概要

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• Enhancement of skin distribution of propylene glycol (PG) in the skin by high purity cis-unsaturated fatty acids with different alkyl chain lengths was studied in the rat using Fourier transform/attenuated total rellection (FT-IR/ATR) analysis. Two fatty acids with the double bond at the Δ9 position, palmitoleic acid (ω7,Δ9) and oleic acid (ω9,Δ9), enhanced PG flux into the dermis and increased the dermal steady state level of PG. In contrast, myristoleic acid (ω5,Δ9) was extremely weak in its action. A positional effect of the ω chain was observed. The rate of skin structural alteration increased in proportion to ω chain length. The application of three fatty acids with the double bond at the ω9 position, oleic acid (ω9,Δ9), gondoic acid (ω9,Δ11), erucic acid (ω9,Δ13) enhanced PG distribution in the skin. While, nervonic acid (ω9,Δ15) did not increase PG distribution in the skin. The relationship of the Δ/ω ratio to parameters characterizing the action of enhancers (PG_<peak area max>, T_<max alteration>, and the slope) sugest that skin distribution increases as the position of the double bond is shifted toward the hydrophilic end. It is therefore likely that the ratio of the Δ/ω chain length of the cis-unsaturated fatty acid determines the efficacy of these compounds as skin penetration enhancers. An adequate molecular volume may be required for cis-unsaturated fatty acids to act as enhancers.

• 社団法人日本薬学会の論文
• 1999-04-15

著者

• 竹内 洋文

  50周年誌編集小委員会

• 鈴木 益子

  仙台真菌研

• FUKUSHIMA Shoji

  Department of Pathology, Osaka City University Medical School

• Fukushima S

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• Takeuchi Yoshikazu

  Lab. Of Clinical Pharmaceutics Fac. Of Pharmaceutical Sciences Kobe Gakuin Univ.

• TAKEUCHI Yoshikazu

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• YAMAOKA Yumiko

  Department of Pharmaceutics, Faculty of Pharmaceutical Science, Kobe Gakuin University

• TAGUCHI Kenji

  Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• SUZUKI Masao

  Oleochemical Research Laboratory, NOF Corporation

• 竹内 豊

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• 鈴木 恵

  Department Of Environmental Science Faculty Of Pharmaceutical Sciences Hokuriku University

• Takeuchi Yoshikazu

  Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Takeuchi Y

  Faculty Of Pharmaceutical Sciences Okayama University

• Yamaoka Takashi

  Pharmacology Research Laboratories Dainippon Sumitomo Pharma Co. Ltd

• Takeuchi Y

  Research Center Sumitomo Pharmaceuticals Co. Ltd.

• Suzuki M

  Advanced Science And Technology Research Center Kyushu University

• Taguchi K

  Department Of Pharmacotherapeutics Showa Pharmaceutical University

• Yamaoka Y

  Kobe‐gakuin Univ. Kobe Jpn

• Yamaoka Yumiko

  Faculty Of Pharmaceutical Sciences And High-technology Research Center Kobe-gakuin University

• Fukushima Shoji

  Department Of Pathology Osaka City University Medical School

• Taguchi Kyoji

  Department Of Pharmacotherapeutics Showa Pharmaceutical University

• Taguchi Kenji

  Department Of Applied Chemistry Nagoya Institute Of Technology

• Fukushima Shoji

  Department Of Gastroenterological Surgery Osaka City University Graduate School Of Medicine

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