EFFECT OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON EXPRESSION OF CELL SURFACE ANTIGENS IN TWO SUBCLONES OF HUMAN LEUKEMIA K562 CELLS
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概要
- 論文の詳細を見る
Two subclones (K562-L and -H) were previously isolated from K562 human leukemic cells according to hemoglobin production : K562-L was expressed in less than 5% and K562-H in more than 90% of dianisidine positive cells. 12-O-Tetradecanoylphorbol-13-acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells. These findings suggest that there are distinct TPA responsible factors in K562-L and -H on the expression of the erythrocytic and myelocytic antigens.
- 公益社団法人日本薬学会の論文
- 1993-10-15
著者
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鈴木 益子
仙台真菌研
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佐々木 大
宮城県赤十字血液センター
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小砂子 智
宮城県赤十字血液センター
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鈴木 益子
Department of Microbiology
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佐々木 大
Department of Microbiology, Tohoku College of Pharmacy
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小砂子 智
Department of Microbiology, Tohoku College of Pharmacy
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三上 健
Department of Microbiology, Tohoku College of Pharmacy
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松本 達二
Department of Microbiology, Tohoku College of Pharmacy
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Suzuki M
Advanced Science And Technology Research Center Kyushu University
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松本 達二
東北薬大
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三上 健
Department Of Microbiology Tohoku Pharmaceutical University
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松本 達二
Department Of Microbiology Tohoku Pharmaceutical University
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