Investigation of Phagocyte-Inducible Factor in Tumor-Implanted Mice
スポンサーリンク
概要
- 論文の詳細を見る
The number of spleen Mac-1-positive cells was markedly increased in methylcholanthrene-induced Meth-A fibrosarcoma (Meth-A)-implanted mice. When the sera of Meth-A-implanted mice were added to normal bone marrow cells, granulocyte and macrophage colony stimulating factor (GM-CSF)-dependent growth of bone marrow cells was significantly enhanced. Analysis of the Meth-A-implanted mice sera showed that the levels of serum transferrin were markedly elevated. When the sera of Meth-A-implanted mice were pretreated with anti-mouse transferrin antibody, the enhancement of GM-CSF-dependent cell growth was almost abolished. Cell growth was also stimulated by the addition of transferrin which also caused an increase in the number of Mac-1-positive cells. Analysis of the effect of transferrin on bone marrow cells showed that the response of the cells to GM-CSF was significantly increased by preincubation with transferrin.
- 公益社団法人日本薬学会の論文
- 1995-12-15
著者
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鈴木 益子
仙台真菌研
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三上 健
東北薬大微生物
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鈴木 益子
Department of Microbiology
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三上 健
Department of Microbiology, Tohoku College of Pharmacy
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松本 達二
Department of Microbiology, Tohoku College of Pharmacy
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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渡部 俊彦
Department of Microbiology, Tohoku College of Pharmacy
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岡田 章利
Department of Microbiology, Tohoku College of Pharmacy
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Suzuki M
Advanced Science And Technology Research Center Kyushu University
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松本 達二
東北薬大
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三上 健
Department Of Microbiology Tohoku Pharmaceutical University
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渡部 俊彦
Department Of Microbiology Tohoku Pharmaceutical University
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松本 達二
Department Of Microbiology Tohoku Pharmaceutical University
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岡田 章利
Department Of Microbiology Tohoku College Of Pharmacy
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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