Antimetastatic Effect of Yeast Mannan-Bleomycin Conjugate against Mouse Lewis Lung Carcinoma
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概要
- 論文の詳細を見る
A conjugate of bleomycin (BLM) and the mannan of bakers' yeast (Saccharomyces cerevisiae wild type strain) (WNM) was synthesized. The assay of its antimetastatic effect on Lewis lung carcinoma (3LL) implanted in C57BL/6 mice showed that this conjugate exhibited a higher antimetastatic effect and longer life-span elongation than those of free bleomycin and mannan with corresponding doses. This conjugate was also found to kill the 3LL cells in vitro. ^<14>C-Labeled mannan-bleomycin conjugate was much more bound that ^<14>C-labeled dextran-bleomycin conjugate to the 3LL. It was concluded that the anti-cancer mechanism of this conjugate, WNM-BLM possessed a specific binding effect to the tumor cells and exhibited a cytocidal effect on the 3LL target cells.
- 公益社団法人日本薬学会の論文
- 1994-05-15
著者
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鈴木 茂生
Second Department of Hygienic Chemistry, Tohoku College of Pharmacy
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鈴木 益子
仙台真菌研
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高橋 信一
東北薬科大学薬学研究科
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鈴木 益子
Department of Microbiology
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三上 健
Department of Microbiology, Tohoku College of Pharmacy
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松本 達二
Department of Microbiology, Tohoku College of Pharmacy
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紺野 由起子
Department of Microbiology Tohoku College of Pharmacy
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高橋 信一
Second Department of Hygienic Chemistry Tohoku College of Pharmacy
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成瀬 竜介
Department of Microbiology Tohoku College of Pharmacy
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紺野 由起子
東北薬科大学
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Suzuki M
Advanced Science And Technology Research Center Kyushu University
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松本 達二
東北薬大
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三上 健
Department Of Microbiology Tohoku Pharmaceutical University
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松本 達二
Department Of Microbiology Tohoku Pharmaceutical University
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