Hyphal Formation of Candida albicans Is Inhibited by Salivary Mucin(Microbiology)
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概要
- 論文の詳細を見る
When mucin was added to Candida albicans under hyphal growth conditions, the hyphal formation was inhibited. After the 24h incubation, the ratio of hyphal cells was 95.1±1.13% in the absence of mucin and no hyphal cells were observed in the presence of 1000μg/ml mucin. The ratio of hyphal cells began to decreases at 6h in the mucin addition group. Although mucin has antifungal activity, the concentration of mucin used in this assay did not inhibit the growth of C. albicans, indicating that the inhibition of hyphal formation was not due to the inhibition of germination by its antifungal activity. Expression of RAS1mRNA in C. albicans was inhibited by mucin. These results suggest that the inhibition of hyphal formation by mucin was caused by interruption of the hyphal formation signal of C. albicans.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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WATANABE Hiromi
Department of Epidemiology and Environmental, Health, Juntendo University School of Medicine
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Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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渡部 俊彦
東北薬大
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Ogasawara Ayako
Department Of Microbiology Tohoku Pharmceutical University
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WATANABE TOSHIHIKO
Department of Surgery, Tachikawa Kyosai Hospital
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Watanabe T
Dept. Clin. Biochem. Sch. Pharm. Sci. Tokyo College Of Pharmacy
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Watanabe T
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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MATSUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmacentical University
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Watanabe Hiromi
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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KOMAKI Nami
Department of Microbiology, Tohoku Pharmaceutical University
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AKAI Hitoshi
Department of Microbiology, Tohoku Pharmaceutical University
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HORI Kumiko
Department of Microbiology, Tohoku Pharmaceutical University
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MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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Konno Nao
Department Of Microbiology Tohoku Pharmaceutical University
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Hori Kumiko
Department Of Microbiology Tohoku Pharmaceutical University
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Komaki Nami
Department Of Microbiology Tohoku Pharmaceutical University
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Akai Hitoshi
Department Of Microbiology Tohoku Pharmaceutical University
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Ogasawara Ayako
Department Of Microbiology Tohoku Pharmaceutical University
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松本 達二
東北薬大
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Watanabe Hiromi
Department Of Microbiology Tohoku Pharmaceutical University
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe Toshihiko
Department Of Aeronautics And Astronautics University Of Tokyo
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Ogasawara Ayako
Department of Microbiology, Tohoku Pharmaceutical University
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松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
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MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
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