Role of Ca^<2+>/Calmodulin Signaling Pathway on Morphological Development of Candida albicans(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
A human fungal pathogen, Candida albicans, varies from the yeast form to the hyphal form due to various external signals. This morphogenetic transformation has been implicated in the development of pathogenicity. In this report, we show that calmodulin inhibitors (TFP and W-7) and an adenylatecyclase inhibitor (MDL-12-330A) suppressed the hyphae formation of C. albicans. Furthermore, the expression of hyphae-specific mRNAs located downstream from the RAS1-cAMP pathway was inhibited by these inhibitors. Suppression of hyphae formation by TFP or W-7 was not inhibited by the addition of cAMP, and these inhibitors did not affect the amount of cAMP in C. albicans. These results suggest that the Ca^<2+>/calmodulin pathway contributes to hyphae formation and is related to the RAS1-cAMP pathway.
- 公益社団法人日本薬学会の論文
- 2004-08-01
著者
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Sato Takashi
Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm
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Mikami Takeshi
Department Of Veterinary Microbiology Faculty Of Agriculture The University Of Tokyo
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Mikami T
Department Of Microbiology Tohoku Pharmceutical University
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Mikami Takeshi
東北薬科大学 微生物学
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渡部 俊彦
東北薬大
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WATANABE TOSHIHIKO
Department of Surgery, Tachikawa Kyosai Hospital
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Watanabe T
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Science Tokyo University Of Pharmacy A
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Mikami Takeshi
Department Of Epizootiology Faculty Of Veterinary Medicine Hokkaido University
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MATSUMOTO Tatsuji
Department of Microbiology, Tohoku Pharmacentical University
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UENO Yukihiro
Department of Microbiology, Tohoku Pharmceutical University
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SATO Tatsuki
Department of Microbiology, Tohoku Pharmaceutical University
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MURAKAMI Tomonori
Department of Microbiology Tohoku College of Pharmacy
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Matsumoto T
Department Of Microbiology Tohoku Pharmceutical University
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Ueno Yukihiro
Department Of Microbiology Tohoku Pharmceutical University
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Ueno Yukihiro
Department Of Critical Care And Emergency Medicine Tsukuba Medical Center
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Watanabe T
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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松本 達二
東北薬大
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Watanabe Toshihiko
Department Of Pediatric Surgery Saitama City Hospital
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Watanabe Takafumi
Department Of Clinical Biochemistry Tokyo College Of Pharmacy:laboratory Of Molecular Biology Azabu
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Watanabe Toshihiko
Department Of Aeronautics And Astronautics University Of Tokyo
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松本 達二
Department of Microbiology, Tohoku Pharmaceutical University
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MIKAMI Takeshi
Department of Cardiovasology, Surugadai Nihon University Hospital
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