The Promoting Effects of Geniposidic Acid and Aucubin in Eucommia ulmoides OLIVER Leaves on Collagen Synthesis

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概要

• 論文の詳細を見る

• We have reported that collagen synthesis was stimulated by the administration of a hot water extract from the leaves of Eucommia ulmoides OLIVER, Eucommiaceae (Du-Zhong leaves) in false aged model rats. In this paper, we set out to examine the compounds in Du-Zhong leaves that stimulated collagen synthesis in false aged model rats. In experiment 1,a methanol extract of Du-Zhong leaves also stimulated collagen synthesis in aged model rats. An acetone fraction was derived from the methanol extract by silica gel chromatography in experiment 2. The acetone fraction mainly contained iridoides mono-glycosides such as geniposidic acid and aucubin.The administration of geniposidic acid or aucubin stimulated collagen synthesis in aged model rats in experiments 3 and 4 (significance (p<0.05)). The reported pharmacological effects of Du-Zhong leaves, including healing organs and strengthening bone and muscle, are closely related to collagen metabolism. It appears that geniposidic acid and aucubin are the actual compounds in Du-Zhong which caused the effect in our experiments.

• 公益社団法人日本薬学会の論文
• 1998-12-15

著者

• Sato T

  Department Of Pathological Biochemistry Kyoto Pharmaceutical University

• Sato Takashi

  Dep. Of Biochemistry And Molecular Biology Tokyo Univ. Of Pharmacy And Life Sciences School Of Pharm

• Motani Kou

  日本大学 薬学部臨床医学ユニット

• Li Yong

  Department Of Chemistry Pukyong National University

• Li Y

  Nihon Univ. Funabashi Jpn

• Metori Koichi

  Chemical Analytical Center College Of Pharmacy Nihon University

• Metori Koichi

  Coll. Of Pharmacy Nihon Univ.

• Metori Koichi

  Department Of Biochemistry College Of Pharmacy Nihon University

• Takahashi S

  秋田県農林水産技術センター総合食品研究所

• LI Yanmei

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• KOIKE Katsuya

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• CHE Qing-ming

  Department of Traditional Chinese Medicine, School of Pharmaceutical Science, Beijing Medical Univer

• METORI Koichi

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• TAKAHASHI Shushichi

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• Li Yanmei

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Koike K

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Koike Katsuya

  Biochemistry Laboratory College Of Pharmacy Nihon University

• Che Qing-ming

  Department Of Traditional Chinese Medicine School Of Pharmaceutical Science Beijing Medical Universi

• Metori K

  College Of Pharmacy Nihon University

• SATO Takahiro

  Biochemistry Laboratory, College of Pharmacy, Nihon University

• Lu Y.M.

  Changchun Institute of Physics Academia Sinica

• Li Y

  Cancer Institute Peking Union Medical College And Chinese Academy Of Medical Sciences

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