Medicinal Foodstuffs. IX. The Inhibitors of glucose Absorption from the Leaves of Gymnema sylvestre R. BR. (Asclepiadaceae) : Structures of Gymnemosides a and b
スポンサーリンク
概要
- 論文の詳細を見る
Although the glycosidic fraction from the dried leaves of Gymnema sylvestre R. BR., gymnemic acid, was reported to be effective for diabetes, it showed little inhibitory activity on the increase of serum glucose level in oral glucose-loaded rats. From the glycosidic fraction, six triterpene glycosides, gymnemosides a, b, c, d, e, and f, were isolated tohether with nine known triterpene glycosides. The structures of gymnemosides a and b were determined on the basis of chemical and physicochemical evidence as 21-O-tigloyl-22-O-acetylgymnemagenin 3-O-β-D-glucopyranosiduronic acid and 16-O-acetyl-21-O-tigloylgymnemagenin 3-O-β-D-glucopyranosiduronic acid, respectively. In addition, an acetyl group linked to the 16- or 22-hydroxyl group in gymnemosides a and b was found to migrate easily to the primary 28-hydroxyl group, while the acyl migration from the 28-position was rarely observed.The inhibitory activity of each trierpene glycoside from gymnemic acid was examined to determine its impact on the increase of serum glucose level in oral glucose-loaded rats. Gymnemoside b and gumnemic acids III, V, and VII were found to exhibit a little inhibitory activity against glucose absorption, but the principal constituents, gymnemic acid I and gymnemasaponin V, lacked this activity.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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村上 啓寿
阪大院薬
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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KADOYA Masashi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Research Institute for Production Development
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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角谷 真
京都薬科大学
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Li Yong
Department Of Chemistry Pukyong National University
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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LI Yuhao
Kyoto Pharmaceutical University
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村上 啓寿
阪大院薬:presto
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Matsumura N
Res. Foundation Itsuu Lab. Tokyo Jpn
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Li Y
Nihon Univ. Funabashi Jpn
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Yamahara J
Kyoto Pharmaceutical University
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Lu Y.M.
Changchun Institute of Physics Academia Sinica
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Li Y
Cancer Institute Peking Union Medical College And Chinese Academy Of Medical Sciences
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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