Effects of Escins Ia, Ib, IIa, and IIb from Horse Chestnut, the Seeds of Aesculus hippocastanum L., on Acute Inflammation in Animals
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概要
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We investigated the effects of escins Ia, Ib, IIa, and IIb isolated from horse chestnut, the seeds of Aesculus hippocastanum L., and desacylescins I and II obtained by alkaline hydrolysis of escins on acute inflammation in animals (p.o.). Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibited the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibited that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibited the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibited the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest. Desacylescins I and II (200 mg/kg) showed no effect. With regard to the relationship between their chemical structures and activities, the acyl groups in escins were essential. Escins Ib, IIa, and IIb with either the 21-angeloyl group or the 2'-O-xylopyranosyl moiety showed more potent activities than escin Ia which had both the 21-tigloyl group and the 2'-O-glucopyranosyl moiety.
- 公益社団法人日本薬学会の論文
- 1997-10-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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NINOMIYA Kiyofumi
Kyoto Pharmaceutical University
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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YAMAHARA Johji
Research Institute for Production Development
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Li Yong
Department Of Chemistry Pukyong National University
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LI Yuhao
Kyoto Pharmaceutical University
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Li Y
Nihon Univ. Funabashi Jpn
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Yamahara J
Kyoto Pharmaceutical University
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Lu Y.M.
Changchun Institute of Physics Academia Sinica
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Li Y
Cancer Institute Peking Union Medical College And Chinese Academy Of Medical Sciences
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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