A New Radical Scavenging Anthracene Glycoside, Asperflavin Ribofuranoside, and Polyketides from a Marine Isolate of the Fungus Microsporum

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概要

• 論文の詳細を見る

• A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), and citrinin (4) have been isolated from the marine-derived fungus Microsporum sp. The structure and absolute stereochemistry of a new compound (1) was assigned on the basis of physicochemical data. Compounds 1-3 exhibited a significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC_<50> values of 14.2, 11.3, and 11.5μM, respectively, which are more potent than the positive control, ascorbic acid (IC_<50>, 20μM). Compound 1 also showed a moderate antibacterial activity against the methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA) with MIC value of 50μg/ml.

• 社団法人日本薬学会の論文
• 2006-06-01

著者

• Choi Hong

  Department of Korean Internal Medicine, College of Oriental Medicine, Daegu Haany University

• Li Y

  Department Of Chemistry Pukyong National University

• Kang Jung

  College Of Dentistry Pusan National University

• Li Yong

  Department Of Chemistry Pukyong National University

• Choi Hong

  Department Of Chemistry Dongeui University

• LI Xifeng

  Department of Chemistry, Pukyong National University

• SON Byeng

  Department of Chemistry, Pukyong National University

• LEE Uk

  Department of Chemistry, Pukyong National University

• Son B

  Department Of Chemistry Pukyong National University

• Son Byeng

  Department Of Chemistry Pukyong National University

• Lee Uk

  Department Of Chemistry Pukyong National University

• Li Xifeng

  Department Of Chemistry Pukyong National University

• Li Yong

  Department Of Anatomy And Cell Biology University Of Pennsylvania School Of Dental Medicine

• Lee Uk

  Department Of Chemistry National Fisheries University Of Pusan

• Choi Hong

  Department of Applied Physics, Korea University, Seoul 136-713, Korea

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