Myrothenones A and B, Cyclopentenone Derivatives with Tyrosinase Inhibitory Activity from the Marine-Derived Fungus Myrothecium sp.
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概要
- 論文の詳細を見る
New 3-amino-5-ethenylcyclopentenones, myrothenones A (4) and B (5), were isolated together with known 6-n-pentyl-α-pyrone (1), trichodenone A (2), and cyclonerodiol (3) from the marine algicolous fungus of genus of Myrothecium. The structure and absolute stereochemistry of the new compounds were established by spectral interpretation and X-ray analysis. Compounds 1 and 4 exhibited a tyrosinase inhibitory activity with IC_<50> value of 0.8 and 6.6μM, respectively, which are more active than kojic acid (IC_<50>, 7.7μM) currently being used as a functional personal-care compound.
- 社団法人日本薬学会の論文
- 2005-04-01
著者
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KIM Min
Department of Internal Medicine, Chonnam National University Hospital
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Kim Se
Department of Radiology, Seoul National University Hospital
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Choi Hong
Department of Korean Internal Medicine, College of Oriental Medicine, Daegu Haany University
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Kang Jung
College Of Dentistry Pusan National University
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Kim Se
Department Of Chemistry Pukyong National University
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Choi Hong
Department Of Chemistry Dongeui University
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LI Xifeng
Department of Chemistry, Pukyong National University
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SON Byeng
Department of Chemistry, Pukyong National University
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LEE Uk
Department of Chemistry, Pukyong National University
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Kim Se
Department Of Anatomy College Of Veterinary Medicine Chonnam National University
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Son B
Department Of Chemistry Pukyong National University
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Son Byeng
Department Of Chemistry Pukyong National University
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Lee Uk
Department Of Chemistry Pukyong National University
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Li Xifeng
Department Of Chemistry Pukyong National University
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Kim Min
Department Of Chemical Engineering Cheju National University
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Lee Uk
Department Of Chemistry National Fisheries University Of Pusan
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Kim Min
Department Of Chemistry Pukyong National University
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Kim Min
Department of Applied Science, Korea Maritime University, Busan 606-791, Korea
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Choi Hong
Department of Applied Physics, Korea University, Seoul 136-713, Korea
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KIM Min
Department of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon 305–764, Korea
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