Transcriptional Induction of Nur77 by Indomethacin That Results in Apoptosis of Colon Cancer Cells
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概要
- 論文の詳細を見る
Non-steroidal anti-inflammatory drugs (NSAIDs) have cancer preventive and tumor regressive effects in the human colon, perhaps due to their capability to induce apoptosis of the colon cancer cells. Here, we report that indomethacin induced the expression of Nur77 which has been implicated in activation-induced apoptosis of T-lymphocytes, in a colon cancer cell line, HCT-15. The transcript- and protein-level, the transcriptional activity of Nur77 promoter, and the DNA binding of Nur77 were significantly induced following indomethacin treatment. Among the two potential trans-acting factors that activate Nur77-promoter, indomethacin induced DNA binding and reporter gene activity of AP-1,but not that of related serum response factor (RSRS), suggesting that the transcriptional induction of Nur77 may be mediated through activation of AP-1. Further, we showed that alltrans-RA repressed the induction of Nur77 as well as the apoptosis-induced by indomethacin, providing evidence that transcriptional induction of Nur77 may be an important mechanism by which indomethacin induces apoptosis in colon cancer cells.
- 公益社団法人日本薬学会の論文
- 2000-07-01
著者
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Kim Se
Department of Radiology, Seoul National University Hospital
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KIM Soo
College of Pharmacy, Kangwon National University
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Choung Se
Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University
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Choung Se
Department Of Hygienic Chemistry College Of Pharmacy Kyung Hee University
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Lee M‐o
Department Of Bioscience And Biotechnology Institute Of Bioscience Sejong University
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Han Sun-young
韓国
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KANG Hyo-Jin
Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University C
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LEE Mi-Ock
Department of Microbiology, Institute for Immunology and Immunological Diseases, Yonsei University C
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Kang H‐j
Kyunghee Univ. Seoul Kor
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Song Moon-jung
Department Of Microbiology Yonsei University College Of Medicine
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Lee Mi-ock
Department Of Microbiology Institute For Immunology And Immunological Diseases Yonsei University Col
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Kim Se
Department Of Microbiology Institute For Immunology And Immunological Diseases Yonsei University Col
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Kim Se
Department Of Anatomy College Of Veterinary Medicine Chonnam National University
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Lee Mi-ock
Department Of Bioscience And Biotechnology Institute Of Bioscience Sejong University
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Kang Hyo-jin
Department Of Bioscience And Biotechnology Institute Of Bioscience Sejong University
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Choung S
Department Of Hygienic Chemistry College Of Pharmacy Kyung Hee University
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