Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)

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概要

• 論文の詳細を見る

• For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoids, sophoraflavanone G, kuraridin, and kurarinone, were isolated. Compared with kojic acid (IC_<50>=20.5μM), these compounds possessed more potent tyrosinase inhibitory activity. The IC50 values were 6.6, 0.6, and 6.2 μM for sophoraflavanone G, kuraridin, and kurarinone, respectively.

• 2003-09-01

著者

• Kim Hyun

  College Of Pharmacy Kangwon National University

• KIM Soo

  College of Pharmacy, Kangwon National University

• SON Kun

  Department of Food Nutrition, Andong National University

• CHANG Hyun

  College of Pharmacy, Yeungnam University

• KANG Sam

  Natural Products Institute, Seoul National University

• Son K

  Department Food & Nutriton Andong National University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Kang Sam

  韓国

• Kang Sam

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kang Sam

  Natural Product Research Institute Seoul National University

• Kim Se

  Department Of Microbiology Institute For Immunology And Immunological Diseases Yonsei University Col

• Chang Hyeun

  Coll. Of Pharmacy Yeungnam Univ.

• Son Kun

  Department Food & Nutriton Andong National University

• Kang S

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kim Soo

  College Of Pharmacy Chungbuk National University

• Chang H

  College Of Pharmacy Yeungnam University

• Kim Hyun

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Kim Hyun

  College Of Electrical & Computer Engineering Chungbuk National University

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