Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid

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概要

• 論文の詳細を見る

• Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentratiOn of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.

• 社団法人日本農芸化学会の論文
• 2000-11-23

著者

• KWON Chong-Suk

  Department of Food Science and Nutrition, Andong National University

• KIM Jong-Sang

  Department of Animal Science and Biotechnology, Kyungpook National University

• Kim Jong-sang

  Dep. Of Animal Sci. And Biotechnology Kyungpook National Univ.

• Son Kun

  Department Food & Nutriton Andong National University

• Kwon Chong-suk

  Dep. Of Food Sci. And Nutrition Andong National Univ.

• KIM JongSang

  Department of Animal Science and Biotechnology, Kyungpook National University

• KWON ChongSuk

  Department of Food Science and Nutrition, Andong National University

• SON KunHo

  Department of Food Science and Nutrition, Andong National University

• Kwon Chong-suk

  Department Of Food Science And Nutrition Andong National University

• Kim Jong-sang

  Department Of Animal Science And Biotechnology Kyungpook National University

• Kwon Chongsuk

  Department Of Food Science And Nutrition Andong National University

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