Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
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概要
- 論文の詳細を見る
Ginkgetin, a biflavone from Ginkgo biloba leaves, was previously reported to be a phospholipase A_2 inhibitor and this compound showed the potent antiarthritic activity in rat adjuvant-induced arthritis as well as analgesic activity. This investigation was carried out to find effects on cyclooxygenase-2 (COX-2) in vitro effect. Ginkgetin inhibits COX-2 dependent phases of prostaglandin D_2 (PGD_2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC_<50> values of 0.75μm. Western blotting probed with specific anti-COX-2 antibodies showed that the decrease in quantity of the PGD_2 product was accompanied by a decrease in the COX-2 protein level. In addition, this compound consistently inhibited the production of leukotriene C_4 (LTC_4) in a dose dependent manner, with an IC_<50> value of 0.33μM. These results demonstrate that ginkgetin has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity. Furthermore, this compound also inhibited degranulation reaction in a dose dependent manner, with an IC_<50> value of 6.52μM. Therefore, this compound might provide a basis for novel anti-inflammatory agents.
- 2005-12-01
著者
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LEE Eunkyung
College of Pharmacy, Yeungnam University
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CHANG Hyeun
College of Pharmacy, Yeungnam University
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Kim Ju
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Kim Hyun
College Of Pharmacy Kangwon National University
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SON Kun
Department of Food Nutrition, Andong National University
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KANG Sam
Natural Products Institute, Seoul National University
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MOON Tae
College of Pharmacy, Yeungnam University
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SON Jong
College of Pharmacy, Yeungnam University
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Kim Jin
韓国
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Son Jong
College Of Pharmacy Yeungnam University
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Son K
Department Food & Nutriton Andong National University
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SON Min
College of Pharmacy, Yeungnam University
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KIM Cheorl
Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University a
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Son Jong
Coll. Of Pharmacy Yeungnam Univ.
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Son J
College Of Pharmacy Yeungnam University
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Chang Hyeun
College Of Pharmacy Yeungnam University
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Kang Sam
韓国
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Moon Tae
韓国
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Moon T
Pulmonary Research Group Department Of Medicine University Of Alberta
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Kang Sam
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Kang Sam
Natural Product Research Institute Seoul National University
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Moon Tae
College Of Pharmacy Yeungnam University
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Kim Cheorl-ho
Dep. Of Biological Sci. Sungkyunkwan Univ.
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Kim Cheorl
Department Of Biochemistry And Molecular Biology College Of Oriental Medicine Dongguk University
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Moon Tae
Pulmonary Research Group Department Of Medicine University Of Alberta
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Chang Hyeun
Coll. Of Pharmacy Yeungnam Univ.
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Son Min
College Of Pharmacy Yeungnam University
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Son Kun
Department Food & Nutriton Andong National University
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Kang S
Natural Products Research Institute And College Of Pharmacy Seoul National University
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Lee E
Yeungnam Univ. Gyongsan Kor
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Kim Cheorl
Department Of Biological Science Sungkyunkwan University
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Chang H
College Of Pharmacy Yeungnam University
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Kim Hyun
College Of Pharmacy And Research Institute Of Drug Development Chonnam National University
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Lee Eunkyung
College Of Pharmacy Yeungnam University
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Kim Hyun
College Of Electrical & Computer Engineering Chungbuk National University
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