Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury
スポンサーリンク
概要
- 論文の詳細を見る
Cimicifuga heracleifolia (CH) ethanol extract and its constituents such as ferulic acid, caffeic acid, 24-epi-7,8-didehydrocimigenol-3-xyloside, and 23-O-acetylshengmanol 3-xyloside were investigated for their abilities to prevent gastric injury. To elucidate their gastric-protective effects, we assessed 1,1-diphenyl-2-picrylhydrazyl radical-radical scavenging activity and inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Ferulic acid and caffeic acid exhibited higher free radical scavenging activity than other constituents and inhibited the colonization of H. pylori effectively. Furthermore, 24-epi-7,8-didehydrocimigenol-3-xyloside and 23-O-acetylshengmanol-3-xyloside showed cytotoxicity in gastric cancer cells (SNU638 and AGS cells). These results suggest the novel activities of CH ethanol extract and its constituents. CH ethanol extract and its constituents could be utilized for the treatment and/or prevention of gastric injury.
- 公益社団法人 日本薬学会の論文
著者
-
SON Kun
Department of Food Nutrition, Andong National University
-
Hwang In
College of Pharmacy, Yeungnam University
-
Son Kun
Department Food & Nutriton Andong National University
-
Kim Mijeong
School of Public, Seoul National University
-
Lee Je-Hyuk
Plant Resources Research Institute, Duksung Womens University
-
Jeong Choon-Sik
College of Pharmacy, Duksung Womens University
-
Jung Joohee
College of Pharmacy, Duksung Womens University
-
Hwang In
College of Pharmacy, Duksung Women's University
-
Jeong Choon-Sik
College of Pharmacy, Duksung Women's University
-
Lee Je-Hyuk
Plant Resources Research Institute, Duksung Women's University
-
Jung Joohee
College of Pharmacy, Duksung Women's University
関連論文
- Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum(Pharmacology)
- Protective Effect of Baicalin Against Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats
- Ochnaflavone, Naturally Occurring Biflavonoid, Inhibits Phospholipase A_2 Dependent Phosphatidylethanolamine Degradation in a CCl_4-Induced Rat Liver Microsome(Biochemistry)
- Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)
- Anti-inflammatory Activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation(Biochemistry)
- Anti-asthmatic Activity of an Ethanol Extract from Saururus chinensis(Biochemistry)
- Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
- Saponins and Other Constituents from the Leaves of Aralia elata
- Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis(Biochemistry/Molecular Biology)
- Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
- Triterpenoid Saponins from the Roots of Sophora koreensis
- Phenolic Glycosides from Pyrola japonica
- Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
- Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)
- Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- Asterosaponins Isolated from the Starfish Asterias amurensis
- Iridoid Esters from Patrinia saniculaefolia
- A New Acylated Triterpene from the Roots of Chaenomeles japonica
- Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica
- Anti-obesity Effect of Dioscorea nipponica Makino with Lipase-inhibitory Activity in Rodents(Food & Nutrition Science)
- Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
- Biflavone Glucosides from Ginkgo biloba Yellow Leaves
- Inhibition of Alpha-glucosidase and Amylase by Luteolin, a Flavonoid
- Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury
- Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of Dioscorea batatas Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells
- Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats
- Anti-gastric Actions of Eugenol and Cinnamic Acid Isolated from Cinnamomi Ramulus
- Luteolin-7-O-glucoside Suppresses Leukotriene C4 Production and Degranulation by Inhibiting the Phosphorylation of Mitogen Activated Protein Kinases and Phospholipase Cγ1 in Activated Mouse Bone Marrow-Derived Mast Cells