Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)

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概要

• 論文の詳細を見る

• Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A_2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and proinflammatory gene expression. When topically applied to ICR mouse ear, ginkgetin (20-80 μg/ear/treatment) inhibited ear edema (22.8-30.5%) and prostaglandin E_2 production (30.2-31.1%) induced by multiple treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 7 consecutive days. By histological comparison, ginkgetin was also found to reduce epidermal hyperplasia. The expression of proinflammatory gene, interleukin-1β, was suppressed by ginkgetin. From the results, it is suggested that ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.

• 2006-05-01

著者

• CHANG Hyeun

  College of Pharmacy, Yeungnam University

• Kim Hyun

  College Of Pharmacy Kangwon National University

• SON Kun

  Department of Food Nutrition, Andong National University

• KANG Sam

  Natural Products Institute, Seoul National University

• LIM Hyun

  College of Pharmacy, Kangwon National University

• Son K

  Department Food & Nutriton Andong National University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Kang Sam

  韓国

• Kang Sam

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kang Sam

  Natural Product Research Institute Seoul National University

• Chang Hyeun

  Coll. Of Pharmacy Yeungnam Univ.

• Son Kun

  Department Food & Nutriton Andong National University

• Kang S

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Lim Hyun

  College Of Pharmacy Kangwon National University

• Chang H

  College Of Pharmacy Yeungnam University

• Kim Hyun

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Kim Hyun

  College Of Electrical & Computer Engineering Chungbuk National University

• Lim Hyun

  Coll. Of Pharmacy Kangwon National Univ. Kor

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