Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells

スポンサーリンク

概要

• 論文の詳細を見る

• In this study, manassantin A (Man A), an herbal medicine isolated from Saururus chinensis (S. chinensis), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC4 generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A2 (cPLA2) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC4 generation by Man A was accompanied by a decrease in cPLA2 phosphorylation, which occurred via the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases.

著者

• Son Jong

  College Of Pharmacy Yeungnam University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Lu Yue

  College of Pharmacy, Yeungnam University

• KWON Okyun

  College of Pharmacy Yeungnam University

• Kim Cheorl-ho

  Department Of Agricultural Chemistry The University Of Tokyo

• Lee Seung

  College Of Pharmacy And Cbitrc Chungbuk National University

• Chang Young-chae

  Department Of Pathology Catholic University Of Daegu School Of Medicine

• Kim Su

  College Of Pharmacy Seoul National University

• Kwon Okyun

  College of Pharmacy, Yeungnam University

• Hwangbo Kyoung

  College of Pharmacy, Yeungnam University

• Seo Chang-Seob

  Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine

関連論文

• Effect of Dexamethasone on STAT6-Dependent Ym1/2 Expression in Vivo and in Vitro(Biochemistry)
• Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum(Pharmacology)
• Ochnaflavone, Naturally Occurring Biflavonoid, Inhibits Phospholipase A_2 Dependent Phosphatidylethanolamine Degradation in a CCl_4-Induced Rat Liver Microsome(Biochemistry)
• Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)
• Anti-inflammatory Activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation(Biochemistry)
• Anti-asthmatic Activity of an Ethanol Extract from Saururus chinensis(Biochemistry)
• Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
• Saponins and Other Constituents from the Leaves of Aralia elata
• Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis(Biochemistry/Molecular Biology)
• Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
• Triterpenoid Saponins from the Roots of Sophora koreensis
• Phenolic Glycosides from Pyrola japonica
• Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
• Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)
• Regulatory Effect of Dosiinpartner on High-Fat Diet-Induced Obesity in C57BL/6J Mice(Pharmacology)
• Dual Inhibition of Cyclooxygenases-2 and 5-Lipoxygenase by Deoxypodophyllotoxin in Mouse Bone Marrow-Derived Mast Cells(Biochemistry/Molecular Biology)
• Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages (Biochemistry/Molecular Biology)
• Antiasthmatic Activity of Luteolin-7-O-glucoside from Ailanthus altissima through the Downregulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model
• The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-kB Activation in RAW264.7 Macrophage Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
• Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
• Expression of Cyclooxygenase-2 and Pro-inflammatory Cytokines Induced by 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) in Human Mast Cells Requires NF-κB Activation
• One-Pot Synthesis of Simple Alkaloids : 2,3-Polymethylene-4(3H)-quinazolinones, Luotonin A, Tryptanthrin, and Rutaecarpine
• Rubus croceacanthus Leveille Inhibits Mast Cell-Mediated Anaphylactic-Like Reaction and Tumor Necrosis Factor-α Secretion(Pharmacology)
• Asterosaponins Isolated from the Starfish Asterias amurensis
• 2-Hydroxycinnamaldehyde Inhibits SW620 Colon Cancer Cell Growth Through AP-1 Inactivation
• Anticancer Constituents from the Roots of Rubia cordifolia L.
• Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection
• Iridoid Esters from Patrinia saniculaefolia
• Detection and Characterization of a Type IIA Secretory Phospholipase A_2 Inhibitory Protein in Human Amniotic Fluid
• cDNA Cloning and Expression of Biologically Active Platelet Activating Factor-Acetylhydrolase (PAF-AH) from Bovine Mammary Gland(Biochemistry/Molecular Biology)
• DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-α Production
• Action of Dracocephalum argunense on Mast Cell-Mediated Allergy Model(Pharmacognosy)
• Inhibitory effect of a traditional Chinese formulation, Hyul-Tong-Ryung, on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells
• Proteome Profiling of U2OS Cell Line in Response to a Prenylphenol Antibiotic Isolated from a Phytopathogenic Fungus(Molecular and Cell Biology)
• Effect of Herbal Medicines on Cytokine-Induced Cytotoxicity and Major Histocompatibility Complex (MHC) Class II Antigen Expression in Rat Thyroid Cells (Pharmacognosy)
• Saucerneol G, a New Lignan, from Saururus chinensis Inhibits Matrix Metalloproteinase-9 Induction via a Nuclear Factor κB and Mitogen Activated Protein Kinases in Lipopolysaccharide-Stimulated RAW264.7 Cells
• Aberrant Expression of Fra-1 in Estrogen Receptor-negative Breast Cancers and Suppression of their Propagation In Vivo by Ascochlorin, an Antibiotic that Inhibits Cellular Activator Protein-1 Activity
• A New Acylated Triterpene from the Roots of Chaenomeles japonica
• Inhibition of Prostaglandin Production by a Structurally-Optimized Flavonoid Derivative, 2',4',7-Trimethoxyflavone and Cellular Action Mechanism(Biochemistry)
• Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica
• Increase of collagen synthesis by obovatol through stimulation of the TGF-β signaling and inhibition of matrix metalloproteinase in UVB-irradiated human fibroblast
• Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
• Change in Action Pattern of Bacillus circulans F-2 Amylase on Partial Hydrolysis with Subtilisin(Biological Chemistry)
• Protective role of Bcl-2 on β-amyloid-induced cell death of differentiated PC12 cells : reduction of NF-κB and p38 MAP kinase activation
• Mushroom Tyrosinase Inhibition Activity of Some Chromones
• Protective Mechanism of Glycyrrhizin on Acute Liver Injury Induced by Carbon Tetrachloride in Mice(Pharmacology)
• Gallotannin Isolated from Euphorbia Species, 1,2,6-Tri-O-galloyl-β-D-allose, Decreases Nitric Oxide Production through Inhibition of Nuclear Factor-κ>B and Downstream Inducible Nitric Oxide Synthase Expression in Macrophages
• Purification and Characterization of 45 kDa PAF Acetylhydrolase from Bovine Colostrum(Biochemistry)
• Spontaneous Ultraweak Photon Emission during the Growth of the Cell Population of Cultured HeLa Cell Line
• Testosterone 5α-Reductase Inhibitors, Menaquinone 7 Produced by a Bacillus and Phenazine Methosulfate
• Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
• Batatasin I, a Naturally Occurring Phenanthrene Derivative, Isolated from Tuberous Roots of Dioscorea batatas Suppresses Eicosanoids Generation and Degranulation in Bone Marrow Derived-Mast Cells
• Spontaneous Ultra-Weak Photon Emission and Delayed Luminescence during Carbon Tetrachloride-Induced Liver Injury and Repair in Mouse
• Anti-Asthmatic Effects of an Amomum compactum Extract on an Ovalbumin (OVA)-Induced Murine Asthma Model
• Luteolin-7-O-glucoside Suppresses Leukotriene C4 Production and Degranulation by Inhibiting the Phosphorylation of Mitogen Activated Protein Kinases and Phospholipase Cγ1 in Activated Mouse Bone Marrow-Derived Mast Cells
• α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)-Inducible Inflammatory Genes in Interferon-γ-Stimulated Macrophages
• Synthesis and Biological Properties of Benzo-Annulated Rutaecarpines
• Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
• Analysis of Cyclin-Dependent Kinase 2-Regulated Phosphorylation of Stathmin in Etoposide-Induced Apoptotic HeLa Cells by Two-Dimensional Electrophoresis and Mass Spectrometry
• Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells
• Involvement of c-Met- and Phosphatidylinositol 3-Kinase Dependent Pathways in Arsenite-Induced Downregulation of Catalase in Hepatoma Cells
• Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells
• Pinusolide Isolated from Biota orientalis Inhibits 5-Lipoxygenase Dependent Leukotriene C4 Generation by Blocking c-Jun N-Terminal Kinase Pathway in Mast Cells
• Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells
• Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-.ALPHA. in Murine Lung Epithelial Cells

もっと見る 閉じる

スポンサーリンク