Effect of Herbal Medicines on Cytokine-Induced Cytotoxicity and Major Histocompatibility Complex (MHC) Class II Antigen Expression in Rat Thyroid Cells (Pharmacognosy)
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概要
- 論文の詳細を見る
The effects of herbal medicines that constitute Gam-du-tang and Gung-gui-tang on cytokine-induced cytotoxicity and thyroid major histocompatibility complex (MHC) class II antigen expression in FRTL rat thyrocytes were investigated. No effect on cell growth was found with interferon (IFN)-γ. However, tumor necrosis factor (TNF)-α was cytotoxic, and this was increased by preincubation with IFN-γ. Ethanol extract of Glycyrrhizae Radix, black beans, Angelicae Radix, and Cnidii Rhizoma (0.3-15 mg/ml) in both regimens significantly inhibited IFN-γ and TNF-α-mediated cytotoxicity of rat thyroid cells (p<0.05, p<0.01). In addition, IFN-γ (1-100 U/ml) treatment induced class II antigen expression in up to 60% of FRTL cells, as detected by a murine monoclonal antibody to rat MHC class II antigen (FITC-OX6). Aberrant thyroid cell MHC class II antigen expression induced by IFN-γ is suppressed by the extract of herbal medicines. These results indicate that herbal medicines inhibit cytokine-induced thyroid cell destruction, therefore, may have therapeutic potential in the treatment of autoimmune thyroid disease.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
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KIM Cheorl-Ho
Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco
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NAM Kyung-Soo
Department of Pharmacology, College of Medicine, Dongguk University
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Nam Kyung-soo
Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive
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Kim Cheorl-ho
Dep. Of Biological Sci. Sungkyunkwan Univ.
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Kim Cheorl-ho
Department Of Agricultural Chemistry The University Of Tokyo
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Kim Cheorl-ho
Department Of Biochemistry College Of Oriental Medicine Dongguk University
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SHON Yun-Hee
Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk Uni
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LEE Hee-Soon
Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk Uni
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LIM Jong-Kook
Department of Acupuncture and Moxibustion-Pointology, College of Oriental Medicine, Dongguk Universi
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JEON Byung-Hun
Department of Pathology, College of Oriental Medicine, Wonkwang University
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Lee H‐s
Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive
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Jeon Byung-hun
Department Of Pathology College Of Oriental Medicine Wonkwang University
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Shon Yun-hee
Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive
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Lim Jong-kook
Department Of Acupuncture And Moxibustion-pointology College Of Oriental Medicine Dongguk University
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Kim Cheorl
Department Of Biological Science Sungkyunkwan University
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Lee Hee-soon
Department Of Pharmacology College Of Medicine And Intractable Disease Research Center Dongguk Unive
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