Deoxypodophyllotoxin Inhibits the Expression of Intercellular Adhesion Molecule-1 Induced by Tumor Necrosis Factor-.ALPHA. in Murine Lung Epithelial Cells

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概要

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• Intercellular adhesion molecule-1 (ICAM-1) is associated with processes of inflammation. We investigated the effects of deoxypodophyllotoxin (DPT) on tumor necrosis factor-α (TNF-α) induced ICAM-1 expression in the mouse lung epithelial cell line, LA4. DPT (5 to 20 nM) inhibited TNF-α-induced ICAM-1 expression through nuclear factor-kappa B (NF-κB) in a dose-dependent manner and repressed ICAM-1 promoter activity. NF-κB reporter gene activity and DNA binding activity were also strongly inhibited. In addition, DPT inhibited degradation by the TNF-α induced inhibitory κB-α (IκB-α) in a concentration-dependent manner. Taken together with our previous results suggest DPT might provide a basis for novel anti-inflammatory drug development.

• 公益社団法人 日本薬学会の論文

著者

• JIN Meihua

  College of Pharmacy, Yeungnam University

• KANG Sanggu

  School of Biotechnology, Yeungnam University

• Chang Hyeun

  College Of Pharmacy Yeungnam University

• Yang Ju

  College of Pharmacy, Yeungnam University

• Lu Yue

  College of Pharmacy, Yeungnam University

• SUH Seok-Jong

  Department of Biological Science, Sungkyunkwan University

• Suh Seok-jong

  Department Of Biological Science Sungkyunkwan University

• Kim Cheorl-ho

  Department Of Agricultural Chemistry The University Of Tokyo

• Yang Ju

  College Of Pharmacy Yeungnam University

• Chang Young-chae

  Research Institute Of Biomedical Engineering And Department Of Medicine Catholic University Of Daegu

• Lee Seung

  College Of Pharmacy And Cbitrc Chungbuk National University

• Lee Eunkyung

  Research And Development Division Daegu Gyeongbuk Institute For Oriental Medicine Industry

• Chang Young-Chae

  Research Institute of Biomedical Engineering, Catholic University of Daegu School of Medicine

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