The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-kB Activation in RAW264.7 Macrophage Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
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概要
- 論文の詳細を見る
Deoxypodophyllotoxin (DPT), a naturally occurring flavolignan with anti-inflammatory activity, was isolated from Anthriscus sylvestris HOFFM., and we examined its effects on the expression of inducible nitric oxide synthase (iNOS) in lipopolv saccharide (LPS)-stimulated, murine macrophage-like RAW264.7 cells. Western blot analysis performed with specific anti-iNOS antibodies showed that a decrease in nitric oxide (NO) was accompanied by a decrease in the iNOS protein level. To clarify the mechanistic basis for DPT's ability to inhibit iNOS induction, we examined the effect of DPT on nuclear factor (NF)-kB transcriptional activity and DNA binding activity. DPT potently suppressed both reporter gene activity and DNA binding activity. These findings suggest that DPT in RAW264.7 cells abolished LPS-induced iNOS expression by inhibiting the transcription factor, NF-kB.
- 社団法人日本薬学会の論文
- 2008-07-01
著者
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JIN Meihua
College of Pharmacy, Yeungnam University
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QUAN Zhejiu
College of Pharmacy, Yeungnam University
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CHANG Hyeun
College of Pharmacy, Yeungnam University
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Kim Yun
Colledge Of Pharmacy Wonkwang University
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LEE Sumg
College of Pharmacy, Yeungnam University
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KIM Cheorl-Ho
Department of Biological Science, Sungkyunkwan University and National Research Laboratory for Glyco
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LEE Seung
College of Pharmacy, Yeungnam University
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Chang Hyeun
College Of Pharmacy Yeungnam University
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Jeong Tae
College of Pharmacy, Yeungnam University
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Kim Yun
College Of Pharmacy Yeungnam University
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Moon Tae
韓国
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Moon T
Pulmonary Research Group Department Of Medicine University Of Alberta
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Yang Ju
College of Pharmacy, Yeungnam University
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Lee Eunkyung
Daegu Gyeongbuk Institute for Oriental Medicine Industry
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MOON Tae
Pulmonary Research Group, Department of Medicine, University of Alberta
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SUH Seok-Jong
Department of Biological Science, Sungkyunkwan University
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Suh Seok-jong
Department Of Biological Science Sungkyunkwan University
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Suh Seok-jong
韓国
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Lee Sumg
College Of Pharmacy Yeungnam University
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Kim Cheorl-ho
Dep. Of Biological Sci. Sungkyunkwan Univ.
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Kim Cheorl-ho
Department Of Agricultural Chemistry The University Of Tokyo
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Moon Tae
Pulmonary Research Group Department Of Medicine University Of Alberta
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Chang Hyeun
Coll. Of Pharmacy Yeungnam Univ.
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Yang Ju
College Of Pharmacy Yeungnam University
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Lee E
Yeungnam Univ. Gyongsan Kor
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Quan Zhejiu
College Of Pharmacy Yeungnam University
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Lee Seung
College Of Pharmacy And Cbitrc Chungbuk National University
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Lee Seung
Department Of Dermatology Seoul National University College Of Medicine Laboratory Of Cutaneous Agin
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Kim Cheorl
Department Of Biological Science Sungkyunkwan University
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Chang H
College Of Pharmacy Yeungnam University
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Jeong Tae
College Of Pharmacy Yeungnam University
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Lee Sun-mee
College Of Pharmacy Yeungnam University
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Jin Mei
College Of Pharmacy Yeungnam University
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Lee Eunkyung
College Of Pharmacy Yeungnam University
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