Butein Ameliorates Renal Concentrating Ability in Cisplatin-Induced Acute Renal Failure in Rats (Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
The present study examined whether the cisplatin-induced nephropathy could be ameliorated by administration of butein isolated from the stems of Rhus verniciflua STOCKS. The present study showed that polyuric profile was revealed in cisplatin-induced acute renal failure (ARF) rats associated with decreases in urinary sodium, potassium, chloride, and creatinine excretion, and osmolality. Among these renal functional parameters, urinary volume and osmolality were partially restored by administration of butein (10mg/kg, i. p.), but electrolytes and creatinine excretion were not restored. Both solute-free water reabsorption and creatinine clearance were also significantly decreased in rats subjected to cisplatin. When butein was administered in rats with cisplatin-induced ARF for 4d, solute-free water reabsorption was improved by 91% compared with that of cisplatin-induced ARF rats, but creatinine clearance was not restored. The expression levels of aquaporin 2 (AQP 2) in the inner, outer medulla, and cortex were significantly decreased in the kidney of ARF, which were partially reverted by administration of butein. In histological examination of the kidney, butein treatment partially prevented the lesions at tubules of renal cortex in cisplatin-induced ARF rats, while the lesions at glomeruli were not ameliorated. Taken together, butein ameliorates renal concentrating ability via up-regulation of renal AQP 2 water channel in rats with cisplatin-induced ARF without ameliorating effect on renal filtration defect.
- 公益社団法人日本薬学会の論文
- 2004-03-01
著者
-
Kim Yun
Colledge Of Pharmacy Wonkwang University
-
Kim Youn
韓国
-
Kim Y
Seoul National Univ. Seoul Kor
-
Woo Won
Department Of Herbal Resources Professional Graduate School Of Oriental Medicine Wonkwang University
-
Moon Mi
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
-
Moon Mi
韓国
-
Lee Hyun
韓国
-
Lee Ho
Professional Graduate School of Oriental Medicine, Wonkwang University
-
Kang Dae
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
-
Lee H
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
-
Lee H
Professional Graduate School Of Oriental Medicine Wonkwang University
-
Lee H
Korea Res. Inst. Biosci. Biotechnol. Taejon Kor
-
Lee Hyun
Cardiovascular Research Laboratory
-
Kim Youn
College Of Pharmacy Wonkwang University
-
LEE Ho
Department of Neurology, School of Medicine, Kyungpook National University
-
LEE An
Professional Graduate School of Oriental Medicine, Wonkwang University
-
Mun Yeon
Department Of Herbal Resources Professional Graduate School Of Oriental Medicine Wonkwang University
-
Lee An
Professional Graduate School Of Oriental Medicine Wonkwang University
-
KANG Dae
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
-
LEE An
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
-
MUN Yeun
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
-
SOHN Eun
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
-
MOON Mi
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
-
Lee Hye
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
-
Sohn Eun
Professional Graduate School Of Oriental Medicine And Medicinal Resources Research Institute (merri)
-
Sohn Eun
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
-
Lee Ho
Department Of Drug Research & Development Korea Institute Of Oriental Medicine
-
Kim Young
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
-
Kim Y
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
-
Lee Ho
Department Of Dermatology Yonsei University College Of Medicine
-
Lee Ho
Department Of Chemistry Stanford University
関連論文
- Anti-Helicobacter pylori Acticvity of Quinolone Alkaloids from Evodiae Fructus
- Effect of Caffeic Acid on Tumor Necrosis Factor-Alpha-Induced Vascular Inflammation in Human Umbilical Vein Endothelial Cells
- The Naturally Occurring Flavolignan, Deoxypodophyllotoxin, Inhibits Lipopolysaccharide-Induced iNOS Expression through the NF-kB Activation in RAW264.7 Macrophage Cells(Highlighted paper selected by Editor-in-chief,Biochemistry)
- In vitro antiproliferative characteristics of flavonoids and diazepam on SNU-C4 colorectal adenocarcinoma cells
- CRM646-A and -B, Novel Fungal Metabolites that Inhibit Heparinase
- CRM-51005, a New Phospholipase C Inhibitor Produced by Unidentified Fungal Strain MT51005
- Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection
- Cornuside Suppresses Cytokine-Induced Proinflammatory and Adhesion Molecules in the Human Umbilical Vein Endothelial Cells(Pharmacognosy)
- Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
- A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
- Microbore high-performance liquid chromatographic determination of cisapride in rat serum samples using column switching
- IS184 Characteristic Features During Spontaneous Termination of Ventricular Tachycardia and Its Degeneration to Ventricular Fibrillation
- Background Nonselective Cationic Current and the Resting Membrane Potential in Rabbit Aorta Endothelial Cells
- Relationship Between Global Cytosolic Ca^ Concentration and Ca^ activated K^+ Current in Rabbit Cerebral Arterial Myocyte
- Phenylpyropene C, a New Inhibitor of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
- Phenylplropene A and B, New Inhibitors of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
- Triterpenoid Saponins from the Seeds of Pharbitis nil
- Pharmacokinetic Disposition of Polyethylene Glycol-Modified Salmon Calcitonins in Rats
- Reversed-phase high-performance liquid chromatography of radioiodinated salmon calcitonins
- Reversed-phase high-performance liquid chromatography of salmon calcitonin and its degradation products in biological samples using column switching and flow-through radioisotope detection
- Synthesis and PPAR-γ Ligand-Binding Activity of the New Series of 2'-Hydroxychalcone and Thiazolidinedione Derivatives
- (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
- Glomerular crescents are responsible for chronic graft dysfunction in post-transplant IgA nephropathy
- Anti-angiogenic and Anti-tumor Activities of 2'-Hydroxy-4'-methoxychalcone(Pharmacology)
- Anti-atherogenic Effects of the Methanol Extract of Sorbus Cortex in Atherogenic-Diet Rats(Pharmacognosy)
- Effect of Methanol Extract of Sorbus Cortex in a Rat Model of L-NAME-Induced Atherosclerosis(Pharmacognosy)
- Butein Ameliorates Renal Concentrating Ability in Cisplatin-Induced Acute Renal Failure in Rats (Pharmacognosy)
- The Properties of Carbachol-Activated Nonselective Cation Channels at the Single Channel Level in Guinea Pig Gastric Myocytes
- Influence of Extracellular Na^+ Removal on Cytosolic Ca^ Concentration in Smooth Muscle Cells of Rabbit Cerebral Artery
- Dual roles of phorbol 12, 13-dibutyrate in the regulation of guinea-pig gastric contraction
- Identification of the modifying sites of mono-PEGylated salmon calcitonins by capillary electrophoresis and MALDI-TOF mass spectrometry
- Evaluation of Musk by Enzyme-Linked Immunosorbent Assay
- Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells
- Rehmannia glutinose Ameliorates Renal Function in the Ischemia/Reperfusion-Induced Acute Renal Failure Rats(Pharmacognosy)
- Vascular Relaxation by the Methanol Extract of Sorbus Cortex via NO-cGMP Pathway(Pharmacognosy)
- Effects of Morin on Blood Pressure and Metabolic Changes in Fructose-Induced Hypertensive Rats(Pharmacology)
- Hypotensive Effect of Butein via the Inhibition of Angiotensin Converting Enzyme(Pharmacology)
- Phenolic Constituents of Galla Rhois with Hepatoprotective Effects on Tacrine- and Nitrofurantoin-Induced Cytotoxicity in Hep G2 Cells(Pharmacognosy)
- White matter hyperintensities in subjects with bipolar disorder
- Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
- Sauchinone, a Lignan from Saururus chinensis, Inhibits Staurosporine-Induced Apoptosis in C6 Rat Glioma Cells(Pharmacognosy)
- Association of estrogen receptor α gene microsatellite polymorphism with annual changes in bone mineral density in Korean women with hormone replacement therapy
- Antimalarial Activity of Lavandulyl Flavanones Isolated from the Roots of Sophora flavescens (Pharmacognosy)
- Direct Sequencing of Superoxide Dismutase Genes from Two Bacterial Strains Amplified by Polymerase Chain Reaction
- Probing of channel formation in organic field effect transistors by optical second harmonic generation measurement
- Effect of Chitosan on Indirubin Production from Suspension Culture of Polygonum tinctorium
- Gastroesophageal flap valve is associated with gastroesophageal and gastropharyngeal reflux
- Effects of Substrate Heating on the Amorphous Structure of InGaZnO Films and the Electrical Properties of Their Thin Film Transistors
- Comuparison of Breakdown Behavior in Electron-Irradiated and Proton-Irradiated Silicon pn Junctions
- Endogenous Gibberellins in Bulbils of Chinese Yam during Growth and Storage(Crop Physiology and Ecology)
- Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells
- Acteoside of Callicarpa dichotoma Attenuates Scopolamine-Induced Memory Impairments(Pharmacology)
- Thirring Model as a Gauge Theory
- Multiple mucosa-associated lymphoid tissue organs involving marginal zone B cell lymphoma : organ-specific relationships and the prognostic factors. Consortium for improving survival of lymphoma study
- Stage IV marginal zone B-cell lymphoma - prognostic factors and the role of rituximab : Consortium for Improving Survival of Lymphoma (CISL) study
- Acquired Blaschko Dermatitis : Acquired Relapsing Self-Healing Blaschko Dermatitis
- Efficient Hole Injection for Top-Emitting Organic Light-Emitting Diodes Using Nickel Oxide by Oxygen Plasma Treatment
- Improved precursor-directed biosynthesis in E. coli via directed evolution
- ISP-5-5 CLEAR CELL CARCINOMA OF OVARY CERVIX AFFECTING THE WOMEN WITH EARLY PREGNANCY(Group 5 Oncology 5,IS Poster,International Session)
- Amorphous Indium Gallium Zinc Oxide Thin-Film Transistors with a Low-Temperature Polymeric Gate Dielectric on a Flexible Substrate
- Waldeyer's ring marginal zone B cell lymphoma : are the clinical and prognostic features nodal or extranodal? : A study by the Consortium for Improving Survival of Lymphoma (CISL)
- Comparison of diagnostic ability between ^Tc-MDP bone scan and ^F-FDG PET/CT for bone metastasis in patients with small cell lung cancer