Hypotensive Effect of Butein via the Inhibition of Angiotensin Converting Enzyme(Pharmacology)
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概要
- 論文の詳細を見る
Butein (3,4,2',4'-tetrahydroxychalcone), a plant pohphenol, has been known to elucidate endothelium-dependent vasodilation. In the present study, the hypotensive effect of butein and its possible mechanism, especially an angiotensin converting enzyme (ACE) inhibitory effect, were investigated. Intravenous injection of butein lowered the arterial blood pressure of anesthetized rats in a dose-dependent manner. The plasma ACE activities were significantly inhibited by the addition of butein in a dose-dependent manner, the IC^<50> value of which was 198 μg/ml (730 μM). Moreover, angiotensin I-induced contraction was markedly attenuated by prior exposure of endothelium-intact aortic rings to butein, but angiotensin II-induced contraction was not altered. These results suggest that butein has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme.
- 公益社団法人日本薬学会の論文
- 2003-09-01
著者
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Kim Yun
Colledge Of Pharmacy Wonkwang University
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Kim Youn
韓国
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Kim Y
Seoul National Univ. Seoul Kor
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Lee Hyun
韓国
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Lee Ho
Professional Graduate School of Oriental Medicine, Wonkwang University
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Lee Yun
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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Kang Dae
Professional Graduate School Of Oriental Medicine Wonkwang Univ.
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LEE Yun
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
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Lee H
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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Lee Y
Professional Graduate School Of Oriental Medicine And Medicinal Resources Research Institute (merri)
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Kim Yun
Medical Research Institute Pusan National University Hospital
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Lee H
Professional Graduate School Of Oriental Medicine Wonkwang University
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Lee H
Korea Res. Inst. Biosci. Biotechnol. Taejon Kor
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Lee Hyun
Cardiovascular Research Laboratory
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LEE Ho
Department of Neurology, School of Medicine, Kyungpook National University
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LEE An
Professional Graduate School of Oriental Medicine, Wonkwang University
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Lee Yun
Department Of Applied Chemistry Saga University
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Lee An
Professional Graduate School Of Oriental Medicine Wonkwang University
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KANG Dae
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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LEE An
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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SOHN Eun
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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Lee Hye
Bioanalysis Laboratory College Of Pharmacy Wonkwang University
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YIN Ming
Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang Universi
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Yin Ming
Department Of Herbal Resources Professional Graduate School Of Oriental Medicine Wonkwang University
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Yin Ming
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Yamanashi University
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Sohn Eun
Professional Graduate School Of Oriental Medicine And Medicinal Resources Research Institute (merri)
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Sohn Eun
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Lee Ho
Department Of Drug Research & Development Korea Institute Of Oriental Medicine
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Kim Young
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Kim Y
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Lee Ho
Department Of Dermatology Yonsei University College Of Medicine
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Lee Ho
Department Of Chemistry Stanford University
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