Preventive Effect of Chlorogenic Acid on Lens Opacity and Cytotoxicity in Human Lens Epithelial Cells
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概要
- 論文の詳細を見る
The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC50 value of 0.95 μM. The xylose-induced opacity of lenses was significantly improved after treatment with chlorogenic acid in a dose-dependent manner. Chlorogenic acid prevented high glucose-induced cytotoxicity in human lens epithelial (HLE-B3) cells in a dose-dependent manner. These results suggest that chlorogenic acid may provide a potential therapeutic approach for prevention of diabetic complications, such as cataracts.
- 公益社団法人 日本薬学会の論文
著者
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Lee Yun
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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KIM Jin
Diabetes Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea I
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Kim Jin
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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Kim Young
Diabetic Complications Res. Center Div. Of Traditional Korean Medicine Integrated Res. Korea Inst. O
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research,
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Kim Young
Diabetic Complications Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea I
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Lee Yun
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine
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Kim Young
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)
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Kim Jin
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)
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