Inhibition of Aldose Reductase and Xylose-Induced Lens Opacity by Puerariafuran from the Roots of Pueraria lobata
スポンサーリンク
概要
- 論文の詳細を見る
High sugar levels found in diabetic cataract cause the opacification of lenses by osmotic changes induced via the aldose reductase (AR)-mediated polyol pathway. In this study, puerariafuran, a 2-arylbenzofuran from Pueraria lobata, investigated the inhibitory effects upon AR, antioxidant contents and enzyme activities in the lens. The effect of puerariafuran on xylose-induced lens opacity was also examined. Puerariafuran showed potential inhibitory activity with an IC50 value of 22.34 μM against rat lens AR. The xylose-induced opacity of lenses was significantly improved when treated with puerariafuran. Xylose exposure of rat lenses significantly decreased the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, superoxide dismutase (SOD), and catalase (CAT) activity and treatment with puerariafuran significantly increased these factors. These results suggest that puerariafuran may provide a potential therapeutic approach for prevention of diabetic complications, such as cataracts.
著者
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Lee Yun
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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JANG Dae
Diabetes Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea I
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KIM Jin
Diabetes Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea I
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Kim Jin
Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins
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Jang Dae
Diabetes Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea Inst. Of Orient
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Kim Young
Diabetic Complications Res. Center Div. Of Traditional Korean Medicine Integrated Res. Korea Inst. O
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research,
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Kim Young
Diabetic Complications Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea I
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine
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Kim Nan
Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine
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Kim Young
Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine
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Kim Jin
Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine
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