Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum

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概要

• 論文の詳細を見る

• A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH_2Cl_2 fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-α-stimulated human colon adeno-carcinoma cell line HT-29 and on the TNF-α secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.

• 公益社団法人日本薬学会の論文
• 2003-05-01

著者

• Kim Young

  College of Pharmacy, Chungnam National University

• KIM Jin

  Departments of Surgery, Seoul National University College of Medicine

• LEE Jung

  Korea Research Institute of Bioscience and Biotechnology

• Lee Yun

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• LEE Young

  Department of Food Science and Nutrition, Pusan National University

• CAI Xing

  College of Pharmacy, Chungnam National University

• Dat N

  College Of Pharmacy Chungnam National University

• Dat Nguyen

  College Of Pharmacy Chungnam National University

• Cai X

  College Of Pharmacy Chungnam National University

• Cai Xing

  College Of Pharmacy Chungnam National University

• Kang Ok

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Kim Young

  College Of Pharmacy Chungnam National University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Kim Jin

  Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar

• Lee Young

  Department Of Aerospace Information Engineering The Konkuk University

• Cai Xing

  Korea Res. Inst. Of Bioscience And Biotechnology Kor

• Lee Young

  Department Of Oriental Pharmacy College Of Pharnacy Wonkwang University

• SHEN Guanghai

  College of Pharmacy, Chungnam National University

• Shen Guanghai

  College Of Pharmacy Chungnam National University

• Lee Jung

  Korea Advanced Institute Of Science And Technology

• Kim Jin

  Department Of Oriental Pharmacy College Of Pharmacy Wonkwang University

• Kim Young

  Colledge of Pharmacy, Wonkwang University

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