Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2(Pharmacognosy)
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概要
- 論文の詳細を見る
In a search for natural product inhibitors of hypoxia inducible factor-1 (HIF-1) function, crinamine (1), a crinane type alkaloid, showed potent dose dependent inhibition (IC_<50>=2.7μM) of HIF-1α in a cell-based reporter gene assay. Crinamine (1) was isolated from the aerial parts of Crinum asiaticum var.japonicum together with lycorine (2), norgalanthamine (3) and epinorgalanthamine (4). The other components (2-4) showed no significant inhibition of HIF-1α induced transcriptional activity.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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Kim Young
College of Pharmacy, Chungnam National University
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Badarch Uranchimeg
Saic-frederick Inc.
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Park Eun
Saic-frederick Inc.
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PARK Mi
College of Pharmacy, Seoul National University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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WOLDEMICHAEL Girma
Molecular Targets Development Program
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BEUTLER John
Molecular Targets Development Program
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Kim Young
College Of Pharmacy Chungnam National University:molecular Targets Development Program:saic-frederic
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Park Mi
College Of Pharmacy Chungnam National University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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