Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
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概要
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The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1—3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC50 ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC50 values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.
著者
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MINH Chau
Institute of Natural Products Chemistry, Vietnamene Academy of Science and Technology
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Kiem Phan
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
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Yen Pham
Institute Of Natural Products Chemistry Vietnam Academy Of Science And Technology
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Nhiem Nguyen
College of Pharmacy, Chungnam National University
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Anh Hoang
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Tai Bui
College of Pharmacy, Chungnam National University
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Koh Young-Sang
School of Medicine, Institute of Medical Sciences, Jeju National University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Thuy Nguyen
Institute Of Archeology
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Hang Dan
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Mathema Vivek
School of Medicine and Brain Korea 21 Program, Jeju National Universit
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Yen Pham
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Kim Young
Colledge of Pharmacy, Wonkwang University
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Kiem Phan
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Minh Chau
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Koh Young-Sang
School of Medicine and Brain Korea 21 Program, Jeju National Universit
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