Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

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概要

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• The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1—3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC50 ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC50 values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.

著者

• MINH Chau

  Institute of Natural Products Chemistry, Vietnamene Academy of Science and Technology

• Kiem Phan

  Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology

• Yen Pham

  Institute Of Natural Products Chemistry Vietnam Academy Of Science And Technology

• Nhiem Nguyen

  College of Pharmacy, Chungnam National University

• Anh Hoang

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Tai Bui

  College of Pharmacy, Chungnam National University

• Koh Young-Sang

  School of Medicine, Institute of Medical Sciences, Jeju National University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Thuy Nguyen

  Institute Of Archeology

• Hang Dan

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Mathema Vivek

  School of Medicine and Brain Korea 21 Program, Jeju National Universit

• Yen Pham

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Kim Young

  Colledge of Pharmacy, Wonkwang University

• Kiem Phan

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Minh Chau

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Koh Young-Sang

  School of Medicine and Brain Korea 21 Program, Jeju National Universit

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