New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
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概要
- 論文の詳細を見る
Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be threo-(7S,8R)-1-(4-hydroxyphenyl)-2-[4-(E)-propenylphenoxy]-propan-1-ol (1), and 5,4'-dihydroxy-7-methoxyflavone-3-O-[α-L-rhamnopyranosyl(1→3)-O-α-L-rhamnopyranosyl(1→6)-O-β-D-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound 1 showed a potent inhibitory activity (IC_<50>=15.6μM),while compounds 4, 5 and 9 showed moderate inhibitory activity (IC_<50> 22.4, 24.5 and 25.7 μM, respectively).
- 公益社団法人日本薬学会の論文
- 2005-01-01
著者
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Kim Young
College of Pharmacy, Chungnam National University
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Kwon Young-in
Dep. Of Food And Nutrition Hannam Univ.
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Kim Young
Coll. Of Pharmacy Chungnam National Univ.
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CAI Xing
College of Pharmacy, Chungnam National University
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Lee I
College Of Pharmacy Chungnam National University
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Dat N
College Of Pharmacy Chungnam National University
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Dat Nguyen
College Of Pharmacy Chungnam National University
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Cai X
College Of Pharmacy Chungnam National University
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Cai Xing
College Of Pharmacy Chungnam National University
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Kim Y
College Of Pharmacy Chungnam National University
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Kim Young
Korea University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Cai Xing
Korea Res. Inst. Of Bioscience And Biotechnology Kor
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Lee Im
College Of Pharmacy Chungnam National University
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SHEN Quanghai
College of Pharmacy, Chungnam National University
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Lee I
Korea Res. Inst. Biosci. And Biotechnol. Taejon Kor
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Shen Quanghai
College Of Pharmacy Chungnam National University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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