Clitocybins, Novel Isoindolinone Free Radical Scavengers, from Mushroom Clitocybe aurantiaca Inhibit Apoptotic Cell Death and Cellular Senescence
スポンサーリンク
概要
- 論文の詳細を見る
High concentration of intracellular reactive oxygen species (ROS) plays a role in damaging biological systems. We isolated clitocybin A from the culture broth of Clitocybe aurantiaca and then clitocybin B and C derivatives were synthesized from clitocybin A. IMR-90 lung fibroblast cells were pre-treated or post-treated with clitocybin A, B and C to the addition of 100 μM H2O2. These compounds inhibited the level of intracellular reactive oxygen species (ROS) and H2O2-induced cell death as judged by hypodiploid cell formation. The inhibitory effect of clitocybins on H2O2-induced cell death was comparable to that with N-acetylcysteine (NAC), a well-known ROS scavenger. The inhibition of H2O2-induced cell death by clitocybins was mediated by the reduction of caspase 3 and 9 activation, cytochrome c release from mitochondria and the degradation of IκB-α and IκB-β, which could be resulted in the prevention of cellular senescence. It suggests that clitocybins are novel compounds scavenging ROS and protect cells from apoptosis and cellular senescence.
- 公益社団法人 日本薬学会の論文
著者
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RYOO In-Ja
Korea Research Institute of Bioscience and Biotechnology
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YOO Ick-Dong
Korea Research Institute of Bioscience and Biotechnology
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Ryoo In-ja
Korea Res. Inst. Of Bioscience And Biotechnology
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Kim Y
College Of Pharmacy Chungnam National University
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Yoo Ick-dong
Korea Res. Inst. Of Bioscience And Biotechnology
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Moon Eun-Yi
Department of Bioscience and Biotechnology, Sejong University
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Oh Jin-Mi
Department of Bioscience and Biotechnology, Sejong University
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Kim Young-Hee
Korea Research Institute of Bioscience and Biotechnology
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Kim Y‐h
Division Of Nuclear Medicine Chonnam University Hospital
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Moon Eun-yi
Department Of Bioscience And Biotechnology Sejong University
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