New Cembranoid Diterpenes from the Vietnamese Soft Coral Sarcophyton mililatensis Stimulate Osteoblastic Differentiation in MC3T3-E1 Cells

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概要

• 論文の詳細を見る

• Chemical investigation of the Vietnamese soft coral Sarcophyton mililatensis resulted in the isolation of four new cembranoid diterpenes, namely (-)-7β-hydroxy-8α-methoxydeepoxysarcophytoxide (1), (+)-7β,8α-dihydroxydeepoxysarcophytoxide (2), (-)-17-hydroxysarcophytonin A (3) and sarcophytol V (4), along with two known compounds, (+)-sarcophine (5) and sarcophytoxide (6). The NMR spectral data of the new compounds were completely assigned by using a combination of 2D NMR experiments including ^1H-^1H COSY, HSQC, HMBC, and ROESY. To investigate the bioactivities of compounds, which act on bone metabolism, we studied the effects of compounds on the function of osteoblastic MC3T3-E1 cells. Compound 1 caused a significant elevation of alkaline phosphatase activity, collagen content, and nodules mineralization compared to those of the control (p<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis.

• 社団法人日本薬学会の論文
• 2008-07-01

著者

• Choi Eun

  College of Pharmacy, Chungnam National University

• Kim Young

  College of Pharmacy, Chungnam National University

• Kwon Young-in

  Dep. Of Food And Nutrition Hannam Univ.

• MINH Chau

  Institute of Natural Products Chemistry, Vietnamene Academy of Science and Technology

• Choi Eun-mi

  Coll. Of Pharmacy Chungnam National Univ. Kor

• Choi Eun

  Coll. Of Pharmacy Chungnam National Univ.

• Kiem Phan

  Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology

• Minh Chau

  Inst. Of Natural Products Chemistry Vietnam Acad. Of Sci. And Technol. (vast)

• Minh C

  Institute Of Natural Products Chemistry Vietnamene Academy Of Science And Technology

• Cuong Nguyen

  Inst. Of Natural Products Chemistry Vietnam Acad. Of Sci. And Technol. (vast)

• Nguyen Xuan

  ベトナム

• Kiem Phan

  Inst. Of Natural Products Chemistry Vietnam Acad. Of Sci. And Technol. (vast)

• Phan Van

  ベトナム

• Kim Young

  Coll. Of Pharmacy Chungnam National Univ.

• CUONG Nguyen

  Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology

• TUAN Tran

  Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology

• Tuan Tran

  Institute Of Natural Products Chemistry Vietnamese Academy Of Science And Technology

• Cuong Nguyen

  Institute Of Chemistry Vietnamese Academy Of Science And Technology

• Kim Y

  College Of Pharmacy Chungnam National University

• Kim Young

  Korea University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Choi Eun

  College Of Pharmacy Chungnam National University

• Cuong Nguyen

  Institute Of Archeology

• Kim Young

  Colledge of Pharmacy, Wonkwang University

• Kiem Phan

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

• Minh Chau

  Institute of Marine Biochemistry, Vietnam Academy of Science and Technology

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