(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
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概要
- 論文の詳細を見る
In the course of screening natural products for anti-acetylcholinesterase(AChE)activity, we found that a total methanolic extract of the underground parts of Caragana chamlague(Leguminosae)had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-α-viniferin(1)and kobophenol A(2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC_<50> values of 1 and 2 were 2.0 and 115.8 μM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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Kim Young
College of Pharmacy, Chungnam National University
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Sung Sang
College of Pharmacy, Seoul National University
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Park Jae-hyuk
Toyohashi Univ. Tech.
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Kim Yun
Colledge Of Pharmacy Wonkwang University
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PARK Jong-Hwan
Department of Laboratory Animal Medicine
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PARK Jae-Hak
Department of Laboratory Animal Medicine
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Park Jae-hak
Dep. Of Lab. Animal Medicine Coll. Of Veterinary Medicine And Krf Zoonotic Disease Priority Res. Ins
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Kim Y
Seoul National Univ. Seoul Kor
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朴 載赫
豊橋技科大
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Kim J
Seoul National Univ. Seoul Kor
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Kim Jeong
College of Oriental Medicine, Kyung Hee University
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Kang So
College Of Pharmacy Seoul National University
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Park J‐h
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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Kim Young
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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KIM Jinwoong
College of Pharmacy, Seoul National University
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Kim Jinwoong
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Park J‐h
Dep. Of Lab. Animal Medicine Coll. Of Veterinary Medicine And Krf Zoonotic Disease Priority Res. Ins
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Park Jong
College Of Pharmacy Pusan National University
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LEE Ki
College of Pharmacy, Seoul National University
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PARK Mi
College of Pharmacy, Seoul National University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Lee Ki
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Sung S
Seoul National Univ. Seoul Kor
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Kim Young
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Lee Ki
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Park Mi
College Of Pharmacy Chungnam National University
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Park Mi
College Of Pharmacy Seoul National University
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Sung Sang
College Of Pharmacy Seoul National University
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Sung Sang
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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