Idesolide, an Isolate of Idesia polycarpa, Inhibits Apoptosis through Induction of Intracellular Heat Shock Protein 70 in C2C12 Muscle Cells

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概要

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• Muscle disorders, such as muscular dystrophy, are associated with an increase in oxidative stress. Proposed treatments for muscular dystrophy, some in clinical trials, include gene therapy and muscle cell transplantation. In this study, we investigated the effects of idesolide, isolated from the fruits of Idesia polycarpa, on changes that occur in muscle disuse atrophy. We noted protective effects on oxidative stress response and HSP70 regulation. Pre-treatment with idesolide for 24 h maintained cell viability and decreased apoptosis in H2O2-treated C2C12 muscle cells. The idesolide pretreatment also increased intracellular HSP70 protein. Our results suggest that idesolide inhibits cell death through induction of HSP70 in C2C12 muscle cells. This work is the first to report that idesolide can regulate the decrease in HSP70 that occurs during skeletal muscle atrophy.

著者

• Jung Min-Ho

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Yoo Jung-Min

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Kang Yeo-Jin

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Lee Hyoung

  Institute for Life Science, Elcomscience Co., Ltd.

• Kim Seung

  Institute for Life Science, Elcomscience Co., Ltd.

• Sung Sang

  College of Pharmacy, Seoul National University

• Lee Yong-Jin

  Chuncheon Bioindustry Foundation

• Choi Inho

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Kim Tack-Joong

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Choi Inho

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Sung Sang

  College Of Pharmacy Seoul National University

• Sung Sang

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Kim Tack-joong

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Kang Yeo-jin

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Yoo Jung-min

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Kim Tack-Joong

  Division of Biological Science and Technology, College of Science and Technology, Institute of Biomaterials, Yonsei University

• Yoo Jung-Min

  Division of Biological Science and Technology, College of Science and Technology, Institute of Biomaterials, Yonsei University

• Jung Min-Ho

  Division of Biological Science and Technology, College of Science and Technology, Institute of Biomaterials, Yonsei University

• Kim Seung

  Institute for Chemical Research, Kyoto University

• Choi Inho

  Division of Biological Science and Technology, College of Science and Technology, Institute of Biomaterials, Yonsei University

関連論文

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