Inhibitory Effect of Eriodictyol on IgE/Ag-Induced Type I Hypersensitivity

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概要

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• Mast cells are the principal effector cells involved in the allergic response, through the release of histamine. We investigated the effect of eriodictyol, derived from the painted maple and yerba santa, on mast cell degranulation and on an allergic response in an animal model. We also investigated its effect on the expression of the ceramide kinase (CERK) involved in calcium-dependent degranulation, and on ceramide activation by multiple cytokines. Eriodictyol suppressed the release of beta-hexosaminidase, a marker of degranulation, and the expression of interleukin (IL)-4 mRNA. It inhibited the expression of CERK mRNA, reduced the ceramide concentration in antigen-stimulated mast cells, and suppressed the passive cutaneous anaphylaxis (PCA) reaction in mice in a dose-dependent manner. These results suggest that eriodictyol can inhibit mast cell degranulation through inhibition of ceramide kinase, and that it might potentially serve as an anti-allergic agent.

• Japan Society for Bioscience, Biotechnology, and Agrochemistryの論文

著者

• Yoo Jung-Min

  Division of Biological Science and Technology, College of Science and Technology, Institute of Bioma

• Kim Tack-joong

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Kang Yeo-jin

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Kim Ji-hee

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• PARK Sae-Jin

  Division of Biological Science and Technology, College of Science and Technology, Yonsei University

• Yoo Jung-min

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

• Park Sae-jin

  Division Of Biological Science And Technology College Of Science And Technology Yonsei University

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