Sauchinone, a Lignan from Saururus chinensis, Attenuates CCl_4-Induced Toxicity in Primary Cultures of Rat Hepatocytes

概要

論文の詳細を見る
We used primary cultures of rat hepatocytes injured by the hepatotoxin, carbon tetrachloride (CCl_4), as a test system to screen for hepatoprotective compounds from natural products. Sauchinone was isolated from the aerial parts of Saururus chinensis (Saururaceae) by this method. At a concentration of 50 μM, sauchinone significantly reduced the release into the culture medium of glutamic pyruvic transaminase from CCl_4-damaged cultures of rat hepatocytes. It has been determined that glutathione, superoxide dismutase and glutathione peroxidase all play important roles in the cellular defense against oxidative stress. Sauchinone appeared to protect primary cultured rat hepatocytes exposed to CCl_4 from significant drops in the levels of each of these three specific markers, respectively. Sauchinone also seemed to ameliorate lipid peroxidation as demonstrated by a reduction in the production of the oxidized lipid byproduct, malondialdehyde. These results suggest that sauchinone may exert hepatoprotective activity through antioxidant activity.
公益社団法人日本薬学会の論文
2000-05-01