Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain

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概要

• 論文の詳細を見る

• The effects of benzylisoquinoline compounds such as ethaverine, laudanosine, and tetrahydropapaverine on monoamine oxidase(MAO, EC 1.4.3.4)activity in mouse brain were investigated. Ethaverine showed an inhibition of MAO activity in a concentration-dependent manner(57.6% inhibition at 40μ_M). Papaverine also inhibited MAO activity(38.1% inhibition at 40μ_M). However, laudanosine and tetrahydropapaverine did not inhibit MAO activity. The IC_<50> value of ethaverine for MAO was 25.5μ_M. Ethaverine non-competitively inhibited MAO activity with a substrate kynuramine. The K_i value for ethaverine was 11.9μ_M. In addition, ethaverine proved to preferentially inhibit type B MAO activity in a concentration-dependent manner, with an IC_<50> value of 32.8μ_M. These results suggest that ethaverine partially contributes to the regulation of catecholamine content.

• 公益社団法人日本薬学会の論文
• 2001-07-01

著者

• Kim Young

  College of Pharmacy, Chungnam National University

• Lee Sang

  College Of Industrial Science Chung-ang University

• Lee M

  College Of Pharmacy Chungbuk National University

• Lee Jae

  College Of Pharmacy And Cbitrc Chungbuk National University

• Lee S

  College Of Pharmacy Chungbuk National University

• Lee Jung

  Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog

• Lee J

  Korea Research Institute Of Bioscience And Biotechnology

• 李 千九

  Faculty Of Pharmaceutical Sciences Kyushu University

• Lee Cheon

  Faculty Of Pharmaceutical Sciences Kyushu University

• Yun Yeo

  College Of Pharmacy Chungbuk National University

• LEE Myung

  College of Pharmacy, Chungbuk National University

• KIM Youngsoo

  College of Pharmacy and Research Center for Bioresources and Health

• Kim Youngsoo

  College Of Pharmacy Chungbuk National University

• Lee M

  Chungbuk National Univ. Chungbuk Kor

• Lee J

  College Of Pharmacy Chungbuk National University

• CHEONG Mi

  College of Pharmacy, Chungbuk National University

• LEE Chong

  College of Pharmacy, Chungbuk National University

• Lee Myung

  College Of Pharmacy Chungbuk National University

• Kim Young

  College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University

• Lee C

  College Of Pharmacy Chungbuk National University

• Lee J

  Anticancer Research Laboratory Korea Research Institute Of Bioscience And Biotechnology

• Cheong Mi

  College Of Pharmacy Chungbuk National University

• Kim Youngsoo

  College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University

• Lee Sang

  College Of Agriculture And Life Sciences Kyungpook National University

• Lee Jae

  College Of Biosciences And Biotechnology Chungnam National University

• Lee Myung

  College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University

• Kim Young

  Colledge of Pharmacy, Wonkwang University

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