Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Dopamine Content in PC12 Cells
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概要
- 論文の詳細を見る
The inhibitory effects of ethaverine on dopamine content in PC12 cells were investigated. Ethaverine decreased dopamine content in a concentration-dependent manner in PC12 cells and showed 33.6% inhibition of dopamine content at a concentration of 1.0μM for 24-48 h. The IC^ value of ethaverine was 1.4μM. Dopamine content was lowered at 6h and reached a minimal level at 12h after exposure to ethaverine at 2.0μM. The decreased dopamine level was maintained up to 48h and then recovered to the control level at about 72h. Tyrosine hydroxylase (TH) was inhibited at 6h following treatment with ethaverine in PC12 cells and the activity was maintained at a reduced level up to 36h (12-22% inhibition at 2.0μM). These results indicate that ethaverine leads to a decrease in dopamine content by inhibition of TH activity.
- 公益社団法人日本薬学会の論文
- 2001-01-01
著者
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Lee M
College Of Pharmacy Chungbuk National University
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Lee Jae
College Of Pharmacy And Cbitrc Chungbuk National University
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Lee Jung
Natural Product Biosynthesis Research Unit Korea Research Institute Of Bioscience & Biotechnolog
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Lee J
Korea Research Institute Of Bioscience And Biotechnology
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李 千九
Faculty Of Pharmaceutical Sciences Kyushu University
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Lee Cheon
Faculty Of Pharmaceutical Sciences Kyushu University
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Yun Yeo
College Of Pharmacy Chungbuk National University
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LEE Myung
College of Pharmacy, Chungbuk National University
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KIM Youngsoo
College of Pharmacy and Research Center for Bioresources and Health
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Kim Youngsoo
College Of Pharmacy Chungbuk National University
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Lee M
Chungbuk National Univ. Chungbuk Kor
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Lee J
College Of Pharmacy Chungbuk National University
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LEE Chong
College of Pharmacy, Chungbuk National University
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SHIN Jung
College of Pharmacy, Chungbuk National University
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Lee Myung
College Of Pharmacy Chungbuk National University
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Lee C
College Of Pharmacy Chungbuk National University
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Lee J
Anticancer Research Laboratory Korea Research Institute Of Bioscience And Biotechnology
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Shin Jung
College Of Pharmacy Chungbuk National University
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Kim Youngsoo
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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Lee Jae
College Of Biosciences And Biotechnology Chungnam National University
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Lee Myung
College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University
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