Anti-inflammatory Benzene Diamine Compound Inhibited Toll-Like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression and Nuclear Factor-KappaB Activation(Pharmacology)

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概要

• 論文の詳細を見る

• Toll-like receptor 4 (TLR4) is known to play an important role in innate immune responses. In the present study, chemically synthetic compound of N^1-benzyl-4-methylbenzene-1,2-diamine (BMD) was discovered to inhibit nitric oxide (NO) production in macrophages RAW 264.7 stimulated with lipopolysaccharide (LPS) or fibronectin as TLR4 activators. The BMD compound attenuated LPS-induced synthesis of both mRNA and protein of NO synthase (iNOS), and inhibited LPS or fibronectin-mediated iNOS promoter activity, indicating that the compound down-regulated iNOS expression at transcription level. As a mode of the anti-inflammatory action shown by BMD compound, inhibitory effect on nuclear factor (NF)-κB activation was also investigated in macrophages RAW 264.7 stimulated with the TLR4 activators.

• 公益社団法人日本薬学会の論文
• 2005-05-01

著者

• KIM Youngsoo

  College of Pharmacy and Research Center for Bioresources and Health

• Kim Youngsoo

  College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University

• Jung Sang

  College Of Pharmacy Chungnam National University

• MIN Kyung

  College of Pharmacy, Chungbuk National University

• Min Kyung

  College Of Pharmacy Chungbuk National University

• KIM Byung

  College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University

• SHIN Hyun

  College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University

• YOON Young

  College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University

• Shin Hyun

  College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University

• Shin Hyun

  College Of Medicine Pochon Cha University

• Kim Byung

  College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University

• Shin Hyun-Mo

  College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University

• Jung Sang-Hum

  College of Pharmacy, Chungnam National University

• MIN Kyung

  College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University

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