Anti-inflammatory Benzene Diamine Compound Inhibited Toll-Like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression and Nuclear Factor-KappaB Activation(Pharmacology)
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概要
- 論文の詳細を見る
Toll-like receptor 4 (TLR4) is known to play an important role in innate immune responses. In the present study, chemically synthetic compound of N^1-benzyl-4-methylbenzene-1,2-diamine (BMD) was discovered to inhibit nitric oxide (NO) production in macrophages RAW 264.7 stimulated with lipopolysaccharide (LPS) or fibronectin as TLR4 activators. The BMD compound attenuated LPS-induced synthesis of both mRNA and protein of NO synthase (iNOS), and inhibited LPS or fibronectin-mediated iNOS promoter activity, indicating that the compound down-regulated iNOS expression at transcription level. As a mode of the anti-inflammatory action shown by BMD compound, inhibitory effect on nuclear factor (NF)-κB activation was also investigated in macrophages RAW 264.7 stimulated with the TLR4 activators.
- 公益社団法人日本薬学会の論文
- 2005-05-01
著者
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KIM Youngsoo
College of Pharmacy and Research Center for Bioresources and Health
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Kim Youngsoo
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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Jung Sang
College Of Pharmacy Chungnam National University
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MIN Kyung
College of Pharmacy, Chungbuk National University
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Min Kyung
College Of Pharmacy Chungbuk National University
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KIM Byung
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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SHIN Hyun
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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YOON Young
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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Shin Hyun
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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Shin Hyun
College Of Medicine Pochon Cha University
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Kim Byung
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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Shin Hyun-Mo
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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Jung Sang-Hum
College of Pharmacy, Chungnam National University
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MIN Kyung
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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