Inhibitory Effects of Anti-Inflammatory Drugs on Interleukin-6 Bioactivity
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概要
- 論文の詳細を見る
Interleukin-6(IL-6)is known as a proinflammatory cytokine involved in immmune response, inflammation, and hematopoiesis. Inhibitory effects of anti-inflammatory drugs on IL-6 bioactivity using IL-6-deoendent hydridoma have been evaluated. Three out of 16 nonsteroidal anti-inflammatory drufs(NSAIDs)showed IC_<50> values of less than 100μ_M, which were in the order of oxyphenylbutazone hydrate(IC_<50>=7.5μ_M)>meclofenamic acid sodium salt(31.9μ_M)>suindac(74.9μ_M). Steroidal anti-inflammatory drugs(SAIDs)exhibited significant inhibitory effects at 100μ_M on the IL-6 bioactivity, and their inhibitory potencies were in the order of budesonide(IC_<50>=2.2μ_M)>hydrobortisone 21-hemisuccinate(6.7μ_M), prednisolone(7.5μ_M), betamethasone(10.9μ_M)>dexamethasone(18.9μ_M)and triamcinolone acetonide(24.1μ_M). The results would provide an additional mechanism by which anti-inflammatory drugs display their anti-inflammatory and immunosuppressive effects at higher concentrations.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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LEE Yong
College of Pharmacy, Seoul National University
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Yun Yeo-Pyo
College of Pharmacy, Chungbuk National University
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Yun Yeo-pyo
College Of Pharmacy Chungbuk National University
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LEE Myung
College of Pharmacy, Chungbuk National University
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KIM Youngsoo
College of Pharmacy and Research Center for Bioresources and Health
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Kim Youngsoo
College Of Pharmacy Chungbuk National University
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Lee Myung
College Of Pharmacy Chungbuk National University
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Lee Ki-sung
Research Center For Niomedical Resources Pai-chai University
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Chung Eun-yong
College Of Pharmacy Chungbuk National University
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Kang B‐s
Dongguk Univ. Kyongju Kor
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Kim Youngsoo
College Of Pharmacy & Research Center For Bioresource And Health Chungbuk National University
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KANG Bo-Seong
College of Pharmacy, Chungbuk National University
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MIN Kyung
College of Pharmacy, Chungbuk National University
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Min Kyung
College Of Pharmacy Chungbuk National University
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Kang Bo-seong
College Of Pharmacy Chungbuk National University
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Lee Myung
College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University
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Lee Yong
College Of Pharmacy Chungbuk National University
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Yun Yeo-pyo
College Of Pharmacy Cbitrc College Of Pharmacy And Medical Research Center Chungbuk National Univers
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Lee Yong
College Of Engineering Yeungnam University
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Yun Yeo-Pyo
College of Pharmacy and Medical Research Center, Chungbuk National University
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MIN Kyung
College of Pharmacy & Research Center for Bioresource and Health, Chungbuk National University
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