第2次性徴決定期に塩化トリプチル錫に暴露されたラットの成熟期における精子形成不全(毒性学)

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概要

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• 50匹の35日齢SDラットを5群に分け,対照群,メチルテストステロン10mg/kg投与群,塩化トリプチル錫5,10,20mg/kg投与群とし,経口投与で10日間連続投与した後,最終投与日から5週間後に殺して実験に供した.塩化トリプチル錫20mg/kg投与群ではホモゲナイゼーション抵抗性の精子数の有意な減少が見られた.また,投与量10mg/kg以上の処理で,有尾の精巣上体精子数の有意な減少が見られた.塩化トリプチル錫20mg/kg投与群のラットの精管から採取した精子の連動パラメータは有意に低下していた.第2次性徴決定期に塩化トリプチル錫に暴露されると成熟期に精巣と精巣上体の精子数の減少および,精管精子の運動パラメータの減少等で特徴付けられる精子形成不全が起こることが明らかになった.

• 社団法人日本獣医学会の論文
• 2003-12-25

著者

• Kim Young

  Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology

• Lee B‐j

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• Lee B‐j

  Seoul National Univ. Seoul Kor

• Yun Y

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine

• Nam S

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine

• Nam Sang-yoon

  韓国

• Nam Sang-yoon

  東京大学 大学院

• Lee Y

  College Of Veterinary Medicine Seoul National University

• Lee Yoon-bok

  韓国

• Lee Yb

  Central Research Institute Dr. Chung's Food Co. Ltd.

• LEE Yong

  College of Pharmacy, Seoul National University

• Kim Yun-bae

  Dep. Of Medicine Univ. Of British Columbia Hospital

• Lee Beom

  College Of Veterinary Medicine Chungbuk National University

• Kim Young

  Department Of Agricultural Chemistry The University Of Tokyo

• Kim Y

  Department Of Public Health College Of Natural Sciences Keimyung University

• NAM Sang

  College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ

• YUN Young

  College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ

• Lee Beom

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• YU Wook

  College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National Univ

• Nam Sang-yoon

  College Of Veterinary Medicine Konkuk University

• Nam Sang

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• Yun Young

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• Lee Y‐b

  Central Research Institute Dr. Chung's Food Co. Ltd.

• Yu Wook

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• Yun Young

  College Of Natural Sciences Department Of Biological Sciences Pusan National University

• Lee B

  College Of Veterinary Medicine And Research Institute Of Veterinary Medicine Chungbuk National Unive

• Lee Yong

  College Of Pharmacy Chungbuk National University

• Lee Yong

  College Of Engineering Yeungnam University

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