Effects of 5-hydroxytryptamine on electrical responses of circular smooth muscle isolated from the guinea-pig gastric antrum
スポンサーリンク
概要
- 論文の詳細を見る
The effects of 5-hydroxytryptamine (5-HT) on electrical responses of the membrane were investigated in circular smooth muscle isolated from the guinea-pig stomach antrum. Small segment of circular muscle tissue produced a periodical generation of slow potentials at frequency of 0.1-2 cycles min^<-1>, during random generation of unitary potentials. Application of 5-HT (10^<-7>-10^<-5>M) hyperpolarized the membrane and either increased or decreased the frequency of slow potentials, both with associated increase in amplitude of slow potential. These effects of 5-HT were abolished by methysergide. N^ω-nitro-L-arginine (L-NA) increased the frequency of spontaneously generated slow potentials and also increased the frequency of slow potentials generated during stimulation with 5-HT, suggesting an involvement of the increased production of nitric oxide (NO) by 5-HT. Atropine did not alter spontaneous and 5-HT-induced electrical responses. The hyperpolarization produced by 5-HT was associated with a decrease in input resistance and time constant of the membrane. The amplitude of the 5-HT-induced hyperpolarization was increased in low [K^+]_0 solution and decreased in high [K^+]_0 solution or in the presence of glybenclamide, suggesting that the hyperpolarization was produced by activation of ATP-sensitive K-channels. The increase in amplitude of slow potentials by 5-HT may be secondary due to hyperpolarization of the membrane. The inhibition by 5-HT of the frequency of slow potentials may be partly due to the increased release of NO, however the mechanism by which dual effects of 5-HT on the frequency of slow potentials remains unsolved.
- 日本平滑筋学会の論文
著者
-
Kobayashi Y
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
-
Kim Young
Department Of Electronics Engineering Korea Advance Intitute Of Science & Technology
-
SUZUKI Hikaru
Department of Physiology, Nagoya City University Medical School
-
NAKAMURA Eri
Department of Physiology, Nagoya City University Medical School
-
KITO Yoshihiko
Department of Physiology, Nagoya City University Medical School
-
Kim Young
Department Of Agricultural Chemistry The University Of Tokyo
-
Kito Yoshihiko
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
-
Suzuki H
Department Of Physiology Nagoya City University Medical School
-
HAYASE Masa
Department of Physiology, Nagoya City University Medical School
-
Kobayashi Yoshinao
Department Of Gastroenterology And Hepatology Division Of Clinical Medicine And Biomedical Science I
-
Suzuki Hikaru
Department Of Physiology Nagoya City University Medical School
-
Suzuki Hikaru
Department Of Cell Physiology Nagoya City University Medical School
-
Kim Young
Department Of Physiology Chungbuk National University College Of Medicine
-
Kamiya Yoshinobu
名古屋市立大学大学院医学研究科消化器・代謝内科学
-
Kito Y
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
-
Hayase Masa
Department Of Nephro-urology Nagoya City University Graduate School Of Medical Sciences
-
Hayase Masa
Department Of Physiology Nagoya City University Medical School
-
Suzuki Hikaru
Dep. Of Cell Physiology
-
Nakamura Eri
Dep. Of Cell Physiology
-
Nakamura Eri
Department Of Cell Physiology Nagoya City University Medical School
-
Suzuki Hikaru
Department Of Cardiology Tokyo Women's Medical University
-
Kuwabara Yoshiyuki
Department Of Oncology Immunology And Surgery Nagoya City University Graduate School Of Medical Scie
-
KITO Yoshihiko
Department of Cell Physiology, Nagoya City University Medical School
関連論文
- IS-85 The relationship between serum follicle-stimulating hormone and estradiol levels and urodynamic results in patients with pelvic floor dysfunction(Group11 Women's Health2,International Session)
- Kaempferol Attenuates 2-Deoxy-D-ribose-Induced Oxidative Cell Damage in MC3T3-E1 Osteoblastic Cells(Biopharmacy)
- Metabolic component of the temperature-sensitivity of slow waves recorded from gastric muscle of the guinea-pig
- ゲニステインとエストラジオールが生殖器の発達に及ぼす影響 : 大豆ベースの餌によって飼育した母マウスから生まれたオスの性成熟への影響(毒性学)
- P1-IS-48 Diabetes Mellitus Following Platinum-Based Chemotherapy in Patients with Gynecologic Malignancy
- P1-IS-38 The Safety and Efficacy of Belotecan in Patients with Recurrent or Refractory Ovarian Cancer
- P1-IS-6 The mRNA and protein expressions of cell division cycle 25 phosphatase in cervical carcinoma and their correlations with clinicopathologic factors
- Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
- USEFULNESS OF THE MEMORY【○!R】8-WIRE BASKET FORCEPS FOR ENDOSCOPIC EXTRACTION OF COMMON BILE DUCT STONES AFTER ENDOSCOPIC SPHINCTEROTOMY
- CLINICAL EVALUATION OF THE HABER RAMP^ CATHETER FOR ENDOSCOPIC BILATERAL METAL STENT PLACEMENT IN PATIENTS WITH MALIGNANT HILAR STRICTURES
- Intracystic hemorrhage of a simple liver cyst mimicking a biliary cystadenocarcinoma
- Effects of RHC-80267, an Inhibitor of Diacylglycerol Lipase, on Excitation of Circular Smooth Muscle of the Guinea-Pig Gastric Antrum
- Dual Effects of Cyclopiazonic Acid on Excitation of Circular Smooth Muscle Isolated from the Guinea-pig Gastric Antrum
- GASTRIC VASCULAR ECTASIA TREATED BY ENDOSCOPIC MUCOSAL RESECTION
- CLINICAL EVALUATION OF DOUBLE STENTING FOR DUODENAL AND BILIARY OBSTRUCTIONS CAUSED BY PANCREATIC HEAD CARCINOMA USING COVERED SELF-EXPANDABLE METALLIC STENTS
- P-IS-44 Correlation of HLA-G gene Expression with Various Prognostic Factors in Ovarian Carcinoma(Oncology 12,Group 99,International Session)
- P-IS-41 Analysis of Chromosomal Changes in Serous Ovarian Carcinoma by Microarray Comparative Genomic Hybridization : Potential Predictive Markers for Chemoresistant Disease(Oncology 11,Group 98,International Session)
- Immunohistochemical analysis of p16INK4A protein overexpression in cervical intraepithelial neoplasia(Oncology 4)
- 2-8.Clinical Usefulness of Cervicogram as Primary Screening Test of Cervical Intraepithelial Neoplasia(Session 3 Oncology 3)
- Flavan-3-ols Having a γ-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro
- Anthraquinones from the Seeds of Cassia tora with Inhibitory Activity on Protein Glycation and Aldose Reductase(Pharmacognosy)
- Puerariafuran, a New Inhibitor of Advanced Glycation End Products (AGEs) Isolated from the Roots of Pueraria lobata
- Efficient Red Electrophosphorescent Devices Based on Iridium Complexes of Fluorinated 1-phenylisoquinoline
- Effects of Indium-Tin-Oxide Surface Treatment on Organic Light-Emitting Diodes
- Adenomyoma of the small intestine in an adult : a rare cause of intussusception
- Effects of Texturing and Microbridge length on the IR Responsivity of YBa_2Cu_3O_x Thin Film
- A Synthesis and Luminescence Study of Ir(ppz)_3 for Organic Light-Emitting Devices
- Accuracy of epidermal growth factor receptor gene mutation analysis by direct sequencing method based on small biopsy specimens from patients with non-small cell lung cancer : analysis of results in 19 patients
- ACPR Improvement Limitations of Predistortion Linearizer for Nonlinear RF Power Amplifiers(Advanced RF Technologies for Compact Wireless Equipment and Mobile Phones)
- Alteration of the responses of gastric smooth muscle to endothelin in streptozotocin-induced diabetic rats
- Improvement of gastric motility by hemodialysis in patients with chronic renal failure
- Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure
- Effects of endothelin-1 on the membrane potential and slow waves in circular smooth muscle of rat gastric antrum
- Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying
- Gastric Myoelectrical Activity in Patients with Recurrent Gastric or Duodenal Ulcers
- Gastric Motility in Patients with Recurrent Gastric Ulcers
- Effects of trimebutine maleate on gastric motility in patients with gastric ulcer
- EXPERIMENTAL APPLICATION OF COMBINED FUZZY AND PREDICTIVE CONTROL TO A BINARY DISTILLATION COLUMN
- MINIMUM DEVIATION ADAPTIVE CONTROL OF A BINARY DISTILLATION COLUMN
- Inhibitory Effect of Poncirus trifoliate on Acetylcholinesterase and Attenuating Activity against Trimethyltin-Induced Learning and Memory Impairment
- Stable Integration and Functional Expression of Flounder Growth Hormone Gene in Transformed Microalga, Chlorella ellipsoidea
- Complementary DNA Encoding nm23/NDP Kinase Gene from the Korean Tiger Shark Scyliorhinus torazame
- IS-95 Sexual behavior of Korean young women : preliminary study for the introducing of HPV prophylactic vaccine(Group12 Oncology4,International Session)
- Prognostic Implication of the Left Atrial Appendage Mechanical Reserve After Cardioversion of Atrial Fibrillation
- Epigenetic markers as promising prognosticators for bladder cancer
- Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats(Pharmacology)
- Roles of Three Well-Conserved Arginine Residues in Mediating the Catalytic Activity of Tobacco Acetohydroxy Acid Synthase
- Isolation and Characterization of Ornithine Decarboxylase Gene from Flounder (Paralichthys olivaceus)
- Mechanism of Cell Cycle Arrest Caused by Histone Deacetylase Inhibitors in Human Carcinoma Cells
- Ischemic Injury-Specific Gene Expression in the Rat Spinal Cord Injury Model Using Hypoxia-Inducible System
- Influence of Inertial Force on Electron Trajectories in the Surface Conduction Electron Emitter Displays
- KANTOROVICH TYPE INEQUALITIES FOR THE DIFFERENCE WITH TWO NEGATIVE PARAMETERS
- 第2次性徴決定期に塩化トリプチル錫に暴露されたラットの成熟期における精子形成不全(毒性学)
- ナノ構造炭化ケイ素セラミックスの機械的特性と接触損傷
- Systematic Lymphadenectomy Improves Survival in Patients with Advanced-Stage Primary Fallopian Tube Cancer
- Effect of Ultrasound on Sludge from Water Treatment Plant
- Background Nonselective Cationic Current and the Resting Membrane Potential in Rabbit Aorta Endothelial Cells
- Relationship Between Global Cytosolic Ca^ Concentration and Ca^ activated K^+ Current in Rabbit Cerebral Arterial Myocyte
- P3-IS-39 The value of vaginal culture for Ureaplasma urealyticum and C-reactive protein as a predictor of adverse pregnancy outcome(Group89 Perinatology+Women's Health1,International Session)
- Analysis of Read-out Signals in Land/Groove Recording of a Phase-Change Optical Disc
- Comparison of Immunological Responses to the Various Types of Circumsporozoite Proteins of Plasmodium vivax in Malaria Patients of Korea
- Residual Stress Behavior of Polyimide Thin Films : Effect of Precursors
- KANTOROVICH TYPE INEQUALITIES CHARACTERIZE THE CHAOTIC ORDER FOR POSITIVE OPERATORS
- Correlation of Serial Cardiac Magnetic Resonance Imaging Parameters With Early Resolution of ST-Segment Elevation After Primary Percutaneous Coronary Intervention
- ビンクロゾリンの生殖毒性 : 性成熟期雄ラットに対する暴露の影響(毒性学)
- The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model
- The changes of serum soluble intercellular adhesion molecule-1 after systemic steroid treatment in vitiligo
- The value of Doppler assessment as a Predictive Factor of Adverse Perinatal Outcome in Intrauterine Growth Restriction (IUGR)(Perinatology 7)
- Effects of Mechanical Stimuli and Microfiber-Based Substrate on Neurite Outgrowth and Guidance(CELL AND TISSUE ENGINEERING)
- Secondary leukemia in a child conceived using in vitro fertilization
- A Novel and Efficient Method for the Technetium-99m Labelling of Disulfide Compounds Using a Tetrahydroborate Exchange Resin
- P-IS-26 Proportion of peripheral blood CD4+CD25high regulatory T cells in patients with gynecologic cancers(Oncology 7,Group 94,International Session)
- Comparative study of laparoscopic radical hysterectomy and radical abdominal hysterectomy in patients with FIGO stage IB cervical cancer(Oncology 9)
- The Properties of Carbachol-Activated Nonselective Cation Channels at the Single Channel Level in Guinea Pig Gastric Myocytes
- Influence of Extracellular Na^+ Removal on Cytosolic Ca^ Concentration in Smooth Muscle Cells of Rabbit Cerebral Artery
- Dual roles of phorbol 12, 13-dibutyrate in the regulation of guinea-pig gastric contraction
- Genetic Diversity of Colored Rice Lines Based on Botanical Characteristics and Simple Sequence Repeat (SSR) Markers
- An in vivo approach for Arabidopsis as a model system for cell biology focused on intracellular trafficking
- Sustainable management of grassland ecosystems for controlling Asian dusts and desertification in Asian continent and a suggestion of Eco-Village study in China
- Angiographic Prevalence and Clinical Predictors of Severely Tortuous Right Subclavian Artery in Patients Undergoing Transradial Coronary Angiography and Interventions
- Antiepileptic Drug Withdrawal after Successful Surgery for Intractable Temporal Lobe Epilepsy
- Effects of NH_3 Plasma Treatment of the Substrate on Metal Organic Chemical Vapor Deposition of Copper Films
- Impact Response of the Intervertebral Disc in a Finite-Element Model
- The Genomic Heterogeneity among Mycobacterium terrae Complex Displayed by Sequencing of 16S rRNA and hsp65 Genes
- Captopril reduces portal pressure effectively in portal hypertensive patients with low portal venous velocity
- Effects of 5-hydroxytryptamine on electrical responses of circular smooth muscle isolated from the guinea-pig gastric antrum
- The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum
- Inhibitory actions of cilostazol on electrical responses of smooth muscle isolated from the guinea-pig stomach antrum
- High-Beam-Current Microcolumns with Large Apertures
- Effect of the Einzel Lens Structure in Microcolumn
- Improvement in Switching Speed of Nematic Liquid Crystal Microlens Array with Polarization Independence
- An Alternative Structure of a Fully Thermally Coupled Distillation Column for Improved Operability
- FLOW CYTOMETRIC DETERMINATION OF THE DNA CONTENT IN TRANSITIONAL CELL CARCINOMA OF THE BLADDER : PREDICTABILITY OF PLOIDY WITH REGARD TO PELVIC LYMPH NODE METASTASIS
- Purification and Characterization of a Copper-Containing Amine Oxidase from Mycobacterium Sp. Strain JC1 DSM 3803 Grown on Benzylamine
- Magnetic Properties in Aligned (Tl_Pb_)Sr_2Ca_2Cu_3O_9 High-T_c Superconductor
- GASTRIC SCHWANNOMA WITH ADJACENT EXTERNAL PROGRESSION HARBORED ABERRANT NF2 GENE
- An Electrical Characteristics-Based Piecewise-Linear DC Model of the MOSFET
- Severe Ascites with Hypothyroidism and Elevated CA125 Concentration : A Case Report
- 日本人における糖尿病を合併するアルツハイマー病の頻度
- Factors which determine the duration of follower potentials in longitudinal smooth muscle isolated from the guinea-pig stomach antrum