Alteration of the responses of gastric smooth muscle to endothelin in streptozotocin-induced diabetic rats
スポンサーリンク
概要
- 論文の詳細を見る
Diabetic gastropathy is suggested to be the result of not only an autonomic neuropathy but also to disorder of the spontaneous rhythmic motility of the gastric smooth muscle. Attempts were made to investigate the alteration of the effects of endothelin-1 (ET-1), which is known to enhance the spontaneous activity of gastrointestinal smooth muscle, on gastric activity in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic rats were prepared by the injection of Sprague-Dawley (SD) rats with STZ (i.p.). Isometric mechanical responses were recorded in isolated circular smooth muscle strips of the stomach antrum, to measure changes in the rhythmicity of the smooth muscle. ET-1 (10nM) significantly elevated the resting tension and the frequency of spontaneous contraction, but did not alter the amplitude of the spontaneous oscillatory contractions in normal rats. In diabetic rats, ET-1 elevated the resting tension, and spontaneous contractions were increased in frequency, however they were decreased in amplitude. In normal rats, sarafotoxin S6c (S6c, 10nM), a selective ET_B receptor agonist, elevated the resting tension slightly and increased both the frequency and amplitude of the spontaneous contractions. However, S6c significantly elevated the resting tension alone in STZ-induced diabetic rats. Selective stimulation of endothelin type A (ET_A) receptors with ET-1, in the presence of a selective antagonist of ET_B receptors, produced similar responses in the gastric muscle of both normal and diabetic rats. These results indicate that ET-1 elevates the resting tension and increases the frequency of the spontaneous oscillatory contractions in both normal and STZ-induced diabetic rats, to a similar extent. However, the specific actions on ET_B receptors were quite different between the two: the elevating actions on the resting tension were much greater in STZ-diabetic rats than in normal rats. The results suggested the facilitation of ET_B receptor signaling in the antrum during the pathogenesis of diabetic gastropathy.
- 日本平滑筋学会の論文
著者
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Kamiya Takeshi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kobayashi Y
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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JOH Takashi
Department of Internal Medicine and Bioregulation, Nagoya City University Medical School
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IMAEDA Kenro
Department of Physiology, Nagoya City University Medical School
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神谷 武志
東大工
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Yamada Kazuhiro
Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
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KATO Takashi
Department of Pharmaceutical Research, Tsukuba Research Laboratories, Eisai Co., Ltd.,
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Tatematsu M
愛知県がんセンター研究所 腫瘍病理学部
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OKAYAMA Naotsuka
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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MIZUNO Tatsuo
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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KIMURA Ryosuke
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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WAKAMI Kazuko
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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RYUGE Fumie
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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KAMIYA Yoshinobu
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sci
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KANEMATSU Takayoshi
Kasugai City Hospital Internal Medicine
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Ryuge Fumie
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Joh T
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Joh Takashi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Wakami Kazuko
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Mizuno Tatsuo
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Imaeda Kenro
名古屋市立大学 医学研究科消化器代謝内科学
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Kimura Ryosuke
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kimura Ryosuke
Department Of Internal Medicine
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Imaeda Kenro
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kato Takashi
Department Of Brain Science And Molecular Imaging National Institute For Longevity Sciences
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Joh Takashi
Department Of Internal Medicine And Bioregulation Nagoya City University Medical School
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Kito Yoshihiko
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Okayama Naotsuka
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Mizushima Takashi
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Yamada Kazuhiro
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Kobayashi Yoshinao
Department Of Gastroenterology And Hepatology Division Of Clinical Medicine And Biomedical Science I
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Kamiya Yoshinobu
名古屋市立大学大学院医学研究科消化器・代謝内科学
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Ogasawara Naotaka
Division Of Oncological Pathology Aichi Cancer Center Research Institute
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Kito Y
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Tanahashi Junji
Intensive Care Unit Kariya General Hospital
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Kuwabara Yoshiyuki
Department Of Oncology Immunology And Surgery Nagoya City University Graduate School Of Medical Scie
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Kamiya Yoshinobu
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Yamada Kazuhiro
Department Of Applied Physics And Physico-informatics Faculty Of Science And Technology Keio University
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Kato Takashi
Department Of Brain Science And Molecular Imaging National Center For Geriatrics And Gerontology
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Kato Takashi
Department Of Applied Chemistry Graduate School Of Engineering Nagoya Institute Of Technology
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KIMURA Ryosuke
Department of Chemical Engineering and Materials Science, Doshisha University
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YAMADA Kazuhiro
Department of Agricultural Chemistry, Tokyo University of Agriculture
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